Senior Director, Translational Medicine - IBD Biomarkers

cAMPfield Therapeutics, Inc.; Boston, San Diego (MA, CA); Hybrid; USD 250,000 - 350,000; Full time

Benefits offered by this job

Equity participation

Flexible hybrid work model

Comprehensive health benefits

Job summary

cAMPfield Therapeutics seeks a Senior Director of Translational Medicine to build and lead a translational strategy linking Prifemilast’s PDE4B mechanism to clinical outcomes in IBD. You will oversee biomarker, pharmacodynamic, endoscopic, and histologic endpoints to inform dose selection and patient stratification.

You will partner across Clinical Development, Pharmacology, and Biostatistics to shape protocol design, data analysis, and regulatory interactions, while mentoring a growing

Qualifications

• PhD, MD, or MD/PhD in immunology, pharmacology, gastroenterology, or a related field.
• 12+ years of translational medicine or translational research experience in biotech or pharma, including direct experience in immune-mediated inflammatory disease (IBD preferred).
• Demonstrated track record of designing and executing biomarker strategies that influenced clinical development decisions (dose selection, go/no-go decisions, patient stratification).
• Deep understanding of GI mucosal immunology and/or PDE4/cAMP signaling biology is a strong plus.
• Experience working with endoscopic and histologic endpoints in IBD trials preferred.
• Strong publication record and experience representing translational science externally to KOLs, regulators, and scientific conferences.
• Demonstrated leadership experience building or managing a translational medicine or biomarker function.
• Excellent cross-functional collaboration skills and comfort operating in a lean, fast-moving biotech environment.

Responsibilities

• Define and lead cAMPfield's translational medicine strategy across the prifemilast clinical program, from Phase 2 through registration-enabling studies.
• Design biomarker, pharmacodynamic, endoscopic, and histopathology sample strategies that link target engagement and mechanism of action to clinical response in IBD.
• Partner with Clinical Development, Clinical Pharmacology, and Biostatistics to integrate translational endpoints into protocol design and data analysis plans.
• Identify and validate biomarkers of disease activity, mucosal healing, and treatment response; explore predictive biomarkers to support patient stratification.
• Evaluate and manage relationships with central reading, histopathology, bioanalytical, and companion diagnostic vendors and academic collaborators.
• Translate emerging preclinical and clinical biomarker data into actionable recommendations for program strategy, including dose selection and lifecycle opportunities.
• Represent translational medicine in regulatory interactions and health authority briefing documents.
• Contribute to scientific publications, congress presentations, and investor/board materials describing prifemilast's mechanism and differentiation.
• Build and mentor a translational medicine function as the organization grows.

Skills

Leadership

Biomarker design

Cross-functional collaboration

Immunology

IBD experience

Education

PhD/MD/MD-PhD in immunology or related field

Job description

cAMPfield Therapeutics seeks a Senior Director of Translational Medicine to build and lead a translational strategy linking Prifemilast’s PDE4B mechanism to clinical outcomes in IBD. You will oversee biomarker, pharmacodynamic, endoscopic, and histologic endpoints to inform dose selection and patient stratification.

You will partner across Clinical Development, Pharmacology, and Biostatistics to shape protocol design, data analysis, and regulatory interactions, while mentoring a growing