Senior Director, Clinical Pharmacology & Modeling

Zai Lab, Ltd.; South San Francisco (CA); On-site; USD 283,000 - 411,000; Full time

Job summary

Zai Lab Limited is seeking an experienced Clinical Pharmacology leader to head the Clinical Pharmacology function and advise on strategy, modeling, and regulatory support across its portfolio. The role requires global collaboration with development, translational sciences, regulatory affairs, and biometrics, based in South San Francisco, CA.

The position emphasizes strategy, quantitative analyses (PK/PD, exposure-response), and leadership of a high-performing team to support global drug

Qualifications

• PhD in Clinical Pharmacology, Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a related field, with 12 years’ relevant experience in drug development; or equivalent combination of higher education, training and experience.

Responsibilities

• Provide strategic leadership for the Clinical Pharmacology function across portfolio programs.
• Develop and implement clinical pharmacology strategies to support global development and registration.
• Lead PK/PD, exposure–response analyses, and human dose projection analyses.
• Collaborate with cross-functional teams to integrate clinical pharmacology into development plans.
• Oversee execution and reporting of pharmacology activities with CROs and partners.
• Prepare pharmacology components of regulatory submissions and interactions.

Skills

Strategic leadership

Clinical pharmacology

PK/PD

Model-informed drug development

Cross-functional collaboration

Regulatory interactions

Education

PhD in Clinical Pharmacology

Tools

PBPK

Population PK

Bioanalytical

Job description

Zai Lab Limited is seeking an experienced Clinical Pharmacology leader to head the Clinical Pharmacology function and advise on strategy, modeling, and regulatory support across its portfolio. The role requires global collaboration with development, translational sciences, regulatory affairs, and biometrics, based in South San Francisco, CA.

The position emphasizes strategy, quantitative analyses (PK/PD, exposure-response), and leadership of a high-performing team to support global drug