Chief of Clinical Pharmacology & Global Development

Zai-Lab-; South San Francisco (CA); On-site; USD 283,000 - 411,000; Full time

Job summary

Zai Lab Limited in South San Francisco, CA invites an experienced Clinical Pharmacology leader to steer the function across small molecules and biologics. You will guide PK/PD modeling, exposure–response analyses, and regulatory interactions while coordinating with DMPK, Translational Sciences, and Regulatory Affairs.

The role emphasizes building a high-performing team, external collaborations with CROs, and strong leadership in a matrix environment to support global development and registration

Qualifications

• PhD in Clinical Pharmacology, Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or a related field, with 12 years' relevant experience in drug development, including industry, regulatory, or other related settings; or equivalent combination of higher education, training and experience.

Responsibilities

• Provide strategic leadership for the Clinical Pharmacology function, including modeling, simulation, and bioanalytical activities across Zai Lab’s portfolio.
• Develop and implement clinical pharmacology strategies to support global development and registration of small molecules, biologics, and other therapeutics.
• Lead clinical pharmacology assessments and quantitative analyses, including PK/PD, exposure–response, and human dose projection.
• Partner with cross-functional teams to integrate clinical pharmacology into development plans.
• Oversee quality and reporting of clinical pharmacology activities, including CROs and external collaborators.
• Lead regulatory submissions and interactions, including INDs and CTAs.
• Evaluate and implement clinical pharmacology technologies to support portfolio needs.
• Build and develop a high-performing Clinical Pharmacology organization.

Skills

Leadership & cross-functional

PK/PD

Model-informed DDD

Regulatory strategy

Education

PhD in Clinical Pharmacology or related field

Tools

PBPK

Population PK

Exposure–Response

Regulatory submissions support

Job description

Zai Lab Limited in South San Francisco, CA invites an experienced Clinical Pharmacology leader to steer the function across small molecules and biologics. You will guide PK/PD modeling, exposure–response analyses, and regulatory interactions while coordinating with DMPK, Translational Sciences, and Regulatory Affairs.

The role emphasizes building a high-performing team, external collaborations with CROs, and strong leadership in a matrix environment to support global development and registration