Senior Director, Cell Line Development & Innovation

Alloy Therapeutics, Inc.; Waltham (MA); On-site; USD 150,000 - 215,000; Full time

Benefits offered by this job

Unlimited PTO

Education stipend

Wellness program

Parental leave

Medical benefits

Disability insurance

Life insurance

Job summary

Alloy Therapeutics, Inc. in Waltham, MA is seeking a Head of Cell Line Development to lead technology evaluation, development, and strategy for stable cell line platforms. This senior role shapes scientific direction and owns projects with cross-functional teams in a dynamic startup environment.

The ideal candidate will have a Ph.D. in a related field, 10+ years of experience with CHO cell lines, and proven leadership of multi-stakeholder programs, including regulatory interactions.

Qualifications

• Ph.D. in Cell Biology, Molecular Biology, Biochemical Engineering, or a related field.
• 10+ years of hands-on experience in cell line development in a CDMO or biotech/pharma setting.
• Proven track record of developing and advancing stable mammalian cell lines (e.g., CHO).
• Deep familiarity with stable transfection and cell line generation technologies.
• Experience leading teams and managing complex, multi-stakeholder technical programs.
• Excellent communication skills for leadership, clients, and regulatory bodies.

Responsibilities

• Lead technology evaluation and development strategy for stable cell line platforms, including host cell engineering, vector design, transfection methods, and clone screening/selection technologies.
• Identify, assess, and implement next‑generation technologies for stable transfection and cell line generation to improve titer, stability, product quality, and speed to clinic.
• Set scientific strategy and roadmap for cell line development capabilities in alignment with broader organizational goals.
• Stay current on emerging trends in stable cell line technologies and evaluate their applicability.
• Represent the organization’s cell line development capabilities in interactions with clients, partners, and at scientific conferences.
• Develop and oversee IP strategy related to proprietary cell line technologies.
• Ensure development activities meet regulatory expectations (ICH Q5D) and support regulatory filings as needed.

Skills

Team leadership

Technical program management

Communication skills

Education

Ph.D. in Cell Biology or related field

Job description

Alloy Therapeutics, Inc. in Waltham, MA is seeking a Head of Cell Line Development to lead technology evaluation, development, and strategy for stable cell line platforms. This senior role shapes scientific direction and owns projects with cross-functional teams in a dynamic startup environment.

The ideal candidate will have a Ph.D. in a related field, 10+ years of experience with CHO cell lines, and proven leadership of multi-stakeholder programs, including regulatory interactions.