Senior Director, ADME Strategy & Execution

Madrigalpharma; Conshohocken (Montgomery County); On-site; USD 256,000 - 313,000; Full time

Benefits offered by this job

Equity

Comprehensive benefits

401(k) with employer match

Job summary

Madrigal is seeking a Senior Director, ADME to provide scientific leadership for ADME activities across nonclinical and clinical programs. You will design strategies, oversee studies, and manage CROs to ensure data quality and regulatory readiness.

The role requires a PhD with 15+ years in ADME, deep metabolism expertise, and experience with PBPK modeling and human mass balance studies. Competitive compensation and comprehensive benefits apply to full-time staff.

Qualifications

• Ph.D. in Pharmacokinetics, Drug Metabolism, Pharmaceutical Sciences, or related field.
• 15+ years of ADME experience in pharmaceutical/biotech drug development.
• Experience supporting both nonclinical and clinical programs.

Responsibilities

• Serve as the ADME subject matter expert with deep metabolism expertise.
• Define and execute ADME strategies with cross-functional leads.
• Design, oversee, and interpret nonclinical ADME studies (in vitro/in vivo).
• Manage CROs including vendor selection, study design, and reports review.
• Author and review ADME sections of regulatory submissions (IND/CTA, NDA).

Skills

ADME expertise

Nonclinical ADME

PBPK modelling

CRO management

Education

PhD in Pharmacokinetics/Drug Metabolism/Pharmaceutical Sciences

Job description

Madrigal is seeking a Senior Director, ADME to provide scientific leadership for ADME activities across nonclinical and clinical programs. You will design strategies, oversee studies, and manage CROs to ensure data quality and regulatory readiness.

The role requires a PhD with 15+ years in ADME, deep metabolism expertise, and experience with PBPK modeling and human mass balance studies. Competitive compensation and comprehensive benefits apply to full-time staff.