Senior Computational Medicinal Chemist - Hybrid in San Diego

Novartis AG; Wyoming; Hybrid; USD 126,000 - 234,000; Full time

Benefits offered by this job

Health, life, and disability benefits

401(k) with company match

Generous time off

Job summary

Novartis AG in San Diego, CA is seeking a Senior Expert I, Data Science to join the Computer-Aided Drug Discovery (CADD) team. You will design and apply advanced computational methods at the interface of chemistry, biology and data science to accelerate target validation and lead optimization.

The role emphasizes machine learning, physics-based modeling and collaboration with cross-functional teams to deliver actionable insights and novel drug candidates in a hybrid work environment.

Qualifications

• PhD in medicinal chemistry, computational chemistry, cheminformatics, computational biology, or a related field.
• 2+ years of related post-graduate experience, preferably in a drug discovery environment.
• Proven track record of innovation through analogue design.
• Familiarity with computational drug design tools (e.g., Schrdoinger, CCG, OpenEye) and HPC.
• Strong publication history in peer-reviewed journals.
• Proactively anticipates project needs with a clinical focus.
• Strong communication and teamwork abilities.
• Proficient in data visualization.

Responsibilities

• Drive the design of medicinal chemistry efforts using SAR, structure- and ligand-based design and PK/PD concepts.
• Leverage machine learning, active learning and physics-based CADD for small molecule discovery.
• Stay current with literature and integrate insights into lead characterization and screening.
• Collaborate with interdisciplinary teams for target ID, lead optimization and candidate nomination.
• Develop predictive models from high-content and time-resolved screening data.
• Lead mechanistic studies using physics-based modeling and biophysical techniques.

Skills

SAR

Structure-based design

Ligand-based design

Target biology

PK/PD

Synthetic feasibility

Machine learning

Active learning

Physics-based CADD

Education

PhD in medicinal chemistry, computational chemistry, cheminformatics, computational biology, or related field

Tools

Schrdoinger

CCG

OpenEye

Job description

Novartis AG in San Diego, CA is seeking a Senior Expert I, Data Science to join the Computer-Aided Drug Discovery (CADD) team. You will design and apply advanced computational methods at the interface of chemistry, biology and data science to accelerate target validation and lead optimization.

The role emphasizes machine learning, physics-based modeling and collaboration with cross-functional teams to deliver actionable insights and novel drug candidates in a hybrid work environment.