Senior Computational Genomics Scientist - AI-Driven Discovery

Vertex Pharmaceuticals Incorporated; San Diego (CA); Hybrid; USD 130,000 - 195,000; Full time

Benefits offered by this job

Bonus

Equity awards

Medical benefits

Paid time off

Commuting subsidy

Job summary

Vertex Pharmaceuticals Incorporated is seeking a Senior Research Scientist in Computational Genomics in San Diego. You will design and lead human genetics studies, translate data into strategic insights, and collaborate across discovery programs to accelerate therapeutic development.

The role emphasizes independent analysis, rigorous interpretation, and expert communication to diverse scientific audiences. The position offers hybrid work with at least three days onsite, with a focus on

Qualifications

• PhD or MSc with extensive experience in human genetics, genomics, or computational biology.
• Proven ability to translate complex datasets into actionable conclusions.
• Proficiency in programming (R, Python) and HPC environments.

Responsibilities

• Design and execute human genetic, genomic, and multi-omic studies to advance target discovery and biomarker development.
• Apply computational and statistical methods to integrate internal and public datasets for insights.
• Own analyses from study design to interpretation and communicate results to diverse audiences.
• Help shape genomics strategies across discovery programs with rigorous study design and analysis plans.
• Collaborate with computational and experimental scientists to apply AI and ML approaches for discovery.

Skills

Genomics & genetics understanding

Data interpretation & communication

Independent problem solving

Team collaboration

Strong scientific judgment

Education

PhD in computational biology / genomics / human genetics

Master's degree with 8+ years industry experience

Tools

R

Python

Unix/Linux

High-Performance Computing

Job description

Vertex Pharmaceuticals Incorporated is seeking a Senior Research Scientist in Computational Genomics in San Diego. You will design and lead human genetics studies, translate data into strategic insights, and collaborate across discovery programs to accelerate therapeutic development.

The role emphasizes independent analysis, rigorous interpretation, and expert communication to diverse scientific audiences. The position offers hybrid work with at least three days onsite, with a focus on