Computational Genomics Scientist - Single-Cell & Spatial

Vertex Pharmaceuticals Incorporated; Boston (MA); Hybrid; USD 112,000 - 168,000; Full time

Benefits offered by this job

Medical, dental, vision benefits

Generous paid time off

Commuting subsidy

401(k) and matching

Student loan repayment support

Job summary

Vertex Pharmaceuticals Incorporated is seeking a Computational Genomics Research Scientist to advance cell and gene therapy programs in Boston. The role integrates diverse genomic datasets, develops analytical workflows, and produces biological insights to drive early research across disease programs.

The position is Boston-based, hybrid (3 days onsite) and lives within Vertex's global Data and Computational Sciences organization, collaborating with stem cell biology, immunology, gene editing,

Qualifications

• Proven track record in genomic data analysis and interpretation.
• Experience with single-cell genomics and spatial transcriptomics experiments.
• Proficiency in Python and/or R for scientific computing.

Responsibilities

• Collaborate with cross-functional teams to address genomic questions.
• Advance spatial transcriptomics methods and share best practices.
• Integrate bulk RNA-seq, single-cell, and spatial data to generate insights.
• Perform rigorous computational analyses with strong statistics and visualization.
• Distill findings into actionable recommendations for research teams.
• Document workflows and ensure reproducibility and traceability.

Skills

Genomic data analysis

Single-cell & spatial transcriptomics

Bioinformatics tools

Statistics

Education

Ph.D. in computational biology / related field

M.S. in related field with 3+ years industry experience

Tools

Python

R

Linux HPC / Cloud

Job description

Vertex Pharmaceuticals Incorporated is seeking a Computational Genomics Research Scientist to advance cell and gene therapy programs in Boston. The role integrates diverse genomic datasets, develops analytical workflows, and produces biological insights to drive early research across disease programs.

The position is Boston-based, hybrid (3 days onsite) and lives within Vertex's global Data and Computational Sciences organization, collaborating with stem cell biology, immunology, gene editing,