Senior Computational Biologist: Single-Cell & AI Analytics

Denali-Therapeutics; South San Francisco (CA); On-site; USD 147,000 - 191,000; Full time

Job summary

Denali Therapeutics seeks a PhD-level computational biologist to oversee and advance analysis of high-dimensional data, including single-cell RNA-seq, across early discovery programs in South San Francisco. The role combines hands-on analytics with strategic oversight, driving target validation and IND-enabling studies.

You will build and adapt pipelines, collaborate with scientists, and manage external partners while contributing to regulatory filings, patents, and publications with rigorous

Qualifications

• PhD required with 3+ years in industry.
• Proven track record of single-cell RNA-seq analysis.
• Experience with high-dimensional data analysis tools (R/Python, Seurat, Scanpy).

Responsibilities

• Lead analysis of high-dimensional data (bulk and single-cell/transcriptomics) across Discovery.
• Collaborate with scientists to design, analyze, and interpret experiments.
• Develop and extend computational tools and workflows; oversee external analyses as needed.
• Communicate results to cross-functional teams and contribute to publications and filings.

Skills

Single-cell RNA-seq analysis

R

Python

Oral and written communication

Education

PhD in Computational Biology / Epidemiology / Neuroscience / Statistics

Tools

Cell Ranger

CellBender

Seurat

scanpy

Git

R Markdown

Quarto

Shiny

Job description

Denali Therapeutics seeks a PhD-level computational biologist to oversee and advance analysis of high-dimensional data, including single-cell RNA-seq, across early discovery programs in South San Francisco. The role combines hands-on analytics with strategic oversight, driving target validation and IND-enabling studies.

You will build and adapt pipelines, collaborate with scientists, and manage external partners while contributing to regulatory filings, patents, and publications with rigorous