Senior Cloud Platform Architect - AI-Driven Leadership

Natera; United States; Hybrid; USD 220,000 - 275,000; Full time

Benefits offered by this job

Annual performance incentive bonus

Long-term equity awards

Comprehensive health benefits

401(k) with company match

Generous paid time off

Job summary

Natera is seeking a Principal Software Engineer to own architecture and delivery of large-scale cloud platforms. You will lead architectural reviews, mentor engineers, and drive AI-native tooling, partnering with bioinformaticians and scientists to translate needs into scalable capabilities.

Location is South San Francisco preferred with remote option. The team operates in a fast-paced, startup-like environment and values practical, MVP-first solutions while maintaining production quality and

Qualifications

• 10+ years of professional software engineering experience across varied system types.
• Production cloud infrastructure experience (AWS preferred; GCP/Azure equivalent acceptable).
• Hands-on Kubernetes, containers, and cluster design experience in production.
• IaC proficiency with Terraform or equivalent tooling.
• Strong programming skills in Python, Go, Java, or similar languages.
• Experience shipping end-user software and influencing multi-quarter initiatives.
• Leadership experience mentoring junior engineers and guiding architecture.

Responsibilities

• Own architecture, design, and delivery of major platform initiatives.
• Lead architecture reviews and help avoid unnecessary complexity.
• Mentor mid-level engineers through code reviews and design docs.
• Develop AI-native tooling and agent-driven workflows.
• Collaborate with scientists and engineers to translate needs into capabilities.

Skills

Cloud infrastructure

Kubernetes

Terraform

Python

Go

Java

Django

React

AI tooling

Technical leadership

Tools

Nextflow

WDL

Airflow

Argo

Temporal

Dagster

Helm

Job description

Natera is seeking a Principal Software Engineer to own architecture and delivery of large-scale cloud platforms. You will lead architectural reviews, mentor engineers, and drive AI-native tooling, partnering with bioinformaticians and scientists to translate needs into scalable capabilities.

Location is South San Francisco preferred with remote option. The team operates in a fast-paced, startup-like environment and values practical, MVP-first solutions while maintaining production quality and