Senior Clinical Trials Manager – Oncology & I&I (Hybrid)

Monte Rosa Therapeutics; Boston (MA); Hybrid; USD 140,000 - 190,000; Full time

Job summary

MRTx is seeking a Sr. Clinical Trial Manager to lead planning, execution, and oversight of phase I–III oncology trials. You will manage budgets, timelines, and CRO/vendor relationships, while developing operational strategy and ensuring adherence to ICH/GCP SOPs. Hybrid work with Boston office; travel 30–40% is required.

The ideal candidate has 8–10 years global clinical trial experience, strong regulatory knowledge, and proven leadership in a fast-paced environment.

Qualifications

• Bachelor's degree in health sciences or related field.
• 8–10 years in global clinical trials and program operations.
• 4+ years independent CTM across start-up to closeout.
• Experience with CRO/vendor oversight and strategic planning.
• Strong knowledge of FDA regulations and ICH/GCP guidelines.
• Excellent communication and cross-functional collaboration.

Responsibilities

• Lead planning, implementation, and conduct of trials across indications.
• Manage study budgets, timelines, and CRO/vendor oversight.
• Develop operational program strategy and KPI tracking.
• Represent Clinical Operations in cross-functional program meetings.
• Mentor junior team members.
• Ensure compliance with ICH/GCP and SOPs.
• Travel 30–40% for site visits and investigator meetings.
• Provide regular reporting to Head of Clinical Operations.

Skills

Clinical operations

Program management

Vendor management

Regulatory knowledge

Communication

Education

Bachelor's degree in health sciences

Tools

Excel

Word

PowerPoint

Outlook

MS Project

Smartsheet

Job description

MRTx is seeking a Sr. Clinical Trial Manager to lead planning, execution, and oversight of phase I–III oncology trials. You will manage budgets, timelines, and CRO/vendor relationships, while developing operational strategy and ensuring adherence to ICH/GCP SOPs. Hybrid work with Boston office; travel 30–40% is required.

The ideal candidate has 8–10 years global clinical trial experience, strong regulatory knowledge, and proven leadership in a fast-paced environment.