Senior Clinical Trial Manager: Decentralized Trials Lead

Neurocentria; Oregon; Hybrid; USD 160,000 - 190,000; Full time

Benefits offered by this job

401(k) plan

Medical, dental, vision insurance

Paid time off

Job summary

Neurocentria is seeking a Senior Clinical Trial Manager to lead two concurrent decentralized Phase 2 trials in neurology and cognitive health. This senior IC role focuses on CRO performance, budgets, timelines, and regulatory compliance across startup to database lock.

You will work closely with the Principal Investigator and Head of Clinical Operations in a lean, science-driven team to ensure successful trial execution and data integrity in a fully decentralized framework.

Qualifications

• Bachelor's degree in life sciences, clinical research, nursing, or related field; advanced degree preferred (MS, MPH, PharmD).
• Minimum 8 years of clinical trial operations experience in pharma/biotech.
• Led at least one Phase 2+ IND-quality trial from startup to database lock.
• Minimum 3 years of direct CRO oversight in sponsor-side role with vendor management.
• Experience with decentralized or hybrid trials, remote management, eConsent, and digital endpoints.
• Strong knowledge of ICH GCP (E6 R2/R3), 21 CFR 312, and eTMF standards.

Responsibilities

• Serve as sponsor-side primary contact for full-service DCT CRO; monitor weekly against deliverables.
• Proactively identify enrollment, screen, dropout, data quality, and timeline risks.
• Lead study startup activities including CRO RFPs, evaluations, and contract reviews; ensure gates cleared.
• Maintain Trial Master File and audit readiness; manage deviations and SAE timelines.
• Oversee trial budgets and CRO invoicing; evaluate change orders and recommend approvals.
• Support IND amendments, IRB submissions, and regulatory interactions as directed.

Skills

Operational leadership

Sponsor-side CRO oversight

DCT / Hybrid trials

ICH GCP knowledge

EDC systems

Budget management

Education

Bachelor's in life sciences or related

Advanced degree preferred (MS, MPH, PharmD)

Tools

REDCap

Medidata Rave

Job description

Neurocentria is seeking a Senior Clinical Trial Manager to lead two concurrent decentralized Phase 2 trials in neurology and cognitive health. This senior IC role focuses on CRO performance, budgets, timelines, and regulatory compliance across startup to database lock.

You will work closely with the Principal Investigator and Head of Clinical Operations in a lean, science-driven team to ensure successful trial execution and data integrity in a fully decentralized framework.