Senior Clinical Research Associate

Immatics; Houston (TX); On-site; USD 120,000 - 135,000; Full time

Benefits offered by this job

Health insurance

401(k) with company match

Paid vacation

Paid holidays

Sick time

Life insurance

Disability coverage

Parental leave

Job summary

Immatics is seeking a Senior Clinical Research Associate to oversee site management and monitoring for oncology trials. The role emphasizes ICH-GCP compliance, FDA/EMA regulations, and collaboration with cross-functional teams to ensure high-quality study execution and patient recruitment.

The position is fully remote in the US, with up to 75% travel, reporting to the Associate Director, Team Lead Site Operations. Competitive benefits are offered.

Qualifications

• Bachelor's degree required in life sciences, nursing, or related field.
• 4+ years of on-site monitoring experience in pharma/biotech.
• Strong knowledge of ICH-GCP, FDA, EMA regulations.
• Experience in monitoring sites, visits, and trial documentation.
• Proficiency with CTMS, eTMF, and MS Office.

Responsibilities

• Conduct all clinical monitoring activities: site qualification, initiation, routine monitoring, close-out visits.
• Support site feasibility, site selection, and ongoing site management across trials.
• Review progress, recruitment, and data quality metrics; implement actions to meet study objectives.
• Maintain monitoring documentation: trip reports and trial master file records.
• Collaborate with vendors, sites, and cross-functional teams for study execution and compliance.
• Mentor junior CRA team members and contribute to process improvements.

Skills

ICH-GCP knowledge

FDA/EMA regulations

Site monitoring

Documentation

CTMS/eTMF proficiency

Microsoft Office

Education

Bachelor's degree in life sciences/nursing

Tools

CTMS

eTMF

Microsoft Office

Job description

Join Immatics and shape the future of cancer immunotherapy; one patient at a time!

Immatics is committed to making a meaningful impact on the lives of patients with cancer. We are the global leader in precision targeting of PRAME, a target expressed in more than 50 cancers. Our cutting-edge science and robust clinical pipeline form the broadest PRAME franchise with the most PRAME indications and modalities, spanning TCR T-cell therapies and TCR bispecifics.

Why Join Us?

• Innovative Environment: Help to pioneer advancements in cancer immunotherapy.
• Collaborative Culture: Be part of a diverse team dedicated to your professional growth.
• Global Impact: Contribute to therapies that make a lasting impact on patients globally.

Role Overview

We are seeking a Senior Clinical Research Associate (CRA) to support our Clinical Operations team. The Senior CRA will be responsible for overseeing clinical trial site management and monitoring activities to ensure compliance with ICH‑GCP, regulatory requirements, and company SOPs. In this role, you will partner closely with clinical sites and cross‑functional teams to support high‑quality study execution, patient recruitment, and operational excellence across clinical trials.

Reports to

Associate Director, Team Lead Site Operations

Location

Fully Remote

Salary Range

$120,000 to $135,000

Basic Qualifications

• Bachelor’s degree in life sciences, nursing, or a related field
• 4+ years of on‑site monitoring experience within the pharmaceutical or biotechnology industry, including all clinical monitoring visit types
• Strong knowledge of ICH‑GCP, FDA, EMA, and applicable clinical trial regulations
• Demonstrated experience managing clinical trial sites, monitoring activities, and clinical trial documentation
• Proficiency with clinical trial systems and tools (e.g., CTMS, eTMF, Microsoft Office)

Preferred Qualifications

• Experience in oncology clinical trials or related therapeutic areas
• Advanced presentation, organizational, and stakeholder management skills
• Experience mentoring or training junior CRAs and supporting cross‑functional clinical operations activities
• Demonstrated ability to drive quality, efficiency, and continuous improvement initiatives in clinical operations
• Strong understanding of clinical trial recruitment strategies, data capture, and site engagement best practices
• Experience contributing to global harmonization, process optimization, or operational innovation initiatives

In This Role You Will

• Conduct all clinical monitoring activities, including site qualification, initiation, routine monitoring, and close‑out visits
• Support site feasibility, site selection, and ongoing site management activities throughout the clinical trial lifecycle
• Review clinical trial progress, patient recruitment, and data quality metrics, and implement actions to support study objectives
• Maintain accurate and timely monitoring documentation, including trip reports and trial master file records
• Collaborate with vendors, clinical sites, and cross‑functional teams to support study execution and operational compliance
• Participate in investigator meetings, clinical trial documentation development, and study team meetings
• Mentor junior CRA team members and contribute to continuous improvement of clinical operations processes and procedures

Travel required

Travel required: Willingness to travel up to 75%. Valid Driver's License preferable.

Qualified candidates will participate in a structured interview process, which includes

• An initial recruiter phone screen (conducted via video)
• A recruiter‑facilitated introduction and interview with the hiring leader and key stakeholders (via video)
• A final‑stage interview, which may include an in‑person meeting at our U.S. Headquarters in Houston, TX

What do we offer?

Comprehensive Benefits

• Competitive rates for Health, Dental, and Vision Insurance
• 4 weeks of vacation, granted up front each year and prorated for first and last year of employment.
• 12 company paid holidays
• 7 days of sick time
• 100% employer‑paid life insuranceup to at 1x annual salary, up to one hundred thousand dollars
• 100% employer‑paid short- and long-Term disability coverage
• 401(k) with immediate eligibilityand company match. The company will match 100% of your contributions up to 3% of your base salary for the first two years of employment, 4% for years 2-3 of employment, and up to 5% of your salary from the fourth year onward of continued employment.
• Partially paid parental leavefor eligible employees.
• Additional voluntary employee‑paid benefits and services, including accident, hospital indemnity, and critical illness insurance, as well as identity theft protection and pet insurance.

Equal Employment Opportunity

We are an equal opportunity employer and are committed to building a diverse and inclusive workplace. We consider all qualified applicants for employment without regard torace, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexualorientation, gender identity or expression, national origin, ancestry, age, marital status, disability, geneticinformation, veteran status, or any other status protected by applicable law.

Reasonable Accommodations

We are committed to providing reasonable accommodations to individuals with disabilities and to applicants withsincerely heldreligious beliefs, practices, or observances. If you require assistance or accommodation during the application or interview process, please contact us [e-mail].

Work Authorization

Applicants mustbe authorized towork in the United States without the need for current or future sponsorship.

Pre‑Employment Requirements

Employment is contingent upon successful completion of a background check, referencechecksand pre-employment drug screening, wherepermittedby applicable law. For certain roles,additionalscreenings such as a credit check or motor vehicle record review may berequired, where job-related and consistent with business necessity.