Senior Clinical Pharmacology Scientist - PK/PD & Modeling

Lilly; Boston (MA); Remote; USD 168,000 - 268,000; Full time

Benefits offered by this job

Company bonus

401(k) program and retirement benefits

Comprehensive health benefits

Vacation and wellness programs

Job summary

Centessa Pharmaceuticals, a clinical-stage company focused on narcolepsy and sleep-wake disorders, seeks a Senior Advisor, Clinical Pharmacology to provide PK/PD depth and quantitative modeling for clinical development. Reporting to the Executive Director, you will build and explain models, translate data into clinical decisions, and lead pharmacology deliverables within project teams.

You will interact with DMPK, translational sciences, regulatory affairs, and biostatistics, overseeing CRO work

Qualifications

• PhD or PharmD in Clinical Pharmacology, Pharmacometrics, Pharmacokinetics, Pharmaceutical Sciences, or a related discipline.
• 3+ years of industry experience in clinical pharmacology or pharmacometrics within biotech, pharmaceutical, or drug development environments.
• Solid working knowledge of PK/PD theory, ADME, DDI mechanisms including in vitro-to-clinical translation, and MIDD principles.
• Hands-on proficiency with appropriate software ( NONMEM, Phoenix WinNonlin, Monolix, R ).
• Ability to explain model assumptions and limitations clearly.
• Working knowledge of FDA/EMA/ICH guidance related to clinical pharmacology.

Responsibilities

• Provide clinical pharmacology and PK/PD input to project teams to guide dose, population, and study design.
• Perform nonclinical and population PK analyses for Phase 1–2 studies.
• Develop exposure–response and PK/PD analyses and PBPK models for dose selection and DDI risk assessment.
• Integrate nonclinical PK/PD with biomarkers for human PK and dose projections.
• Draft PK/PD sections of clinical development documents.
• Collaborate with cross-functional teams across DMPK, translational sciences, clinical development, regulatory affairs and project leadership.
• Oversee CRO work and review analyses and reports.
• Present findings to internal stakeholders and contribute to publications.

Skills

PK/PD theory

NONMEM

Phoenix WinNonlin

Monolix

R

Cross-functional collaboration

Communication skills

Education

PhD or PharmD in Clinical Pharmacology

Tools

NONMEM

Phoenix WinNonlin/NLME

Monolix

R

Job description

Centessa Pharmaceuticals, a clinical-stage company focused on narcolepsy and sleep-wake disorders, seeks a Senior Advisor, Clinical Pharmacology to provide PK/PD depth and quantitative modeling for clinical development. Reporting to the Executive Director, you will build and explain models, translate data into clinical decisions, and lead pharmacology deliverables within project teams.

You will interact with DMPK, translational sciences, regulatory affairs, and biostatistics, overseeing CRO work