Senior Director, CNS Clinical Development (Remote)

Eli Lilly and Company; Boston (MA); Remote; USD 201,000 - 356,000; Full time

Job summary

Centessa Pharmaceuticals is seeking an Executive/Senior Director of Clinical Development to lead early-stage orexin receptor program initiatives in CNS indications. You will drive strategic and operational execution across preclinical translation through late-stage trials, partnering with Regulatory, Translational Medicine, and Biometrics teams to deliver safe, effective therapies.

The role emphasizes scientific leadership, cross-functional collaboration, and regulatory interactions, with a

Qualifications

• MD in Neurology or Psychiatry with board certification preferred.
• 8+ years in the pharmaceutical industry.
• Experience in early clinical development through late-stage programs; neuroscience submission experience desired.
• Knowledge of US/EU regulatory guidelines and interactions with regulatory agencies.
• Excellent written and verbal communication with cross-functional stakeholder engagement.

Responsibilities

• Serve as clinical leader for assigned early-stage programs, with medical and scientific ownership.
• Author and oversee clinical study protocols for orexin receptor agonists with scientific rigor and regulatory alignment.
• Contribute to integrated clinical development plans spanning preclinical to late-stage trials.
• Collaborate with Clinical Operations to meet quality, timelines, and budget across studies.
• Provide real-time medical and scientific guidance for ongoing trials, including safety oversight.
• Support biomarker strategy, dose selection, and indication expansion opportunities.
• Communicate clinical updates across internal teams and external stakeholders.
• Contribute to regulatory submissions including INDs, amendments, and clinical study reports.
• Ensure robust safety monitoring and adherence to GCP and pharmacovigilance standards.

Skills

Leadership

Cross-functional collaboration

Strategic thinking

Communication

Regulatory interactions

Education

MD in Neurology or Psychiatry

Board certification preferred

Job description

Centessa Pharmaceuticals is seeking an Executive/Senior Director of Clinical Development to lead early-stage orexin receptor program initiatives in CNS indications. You will drive strategic and operational execution across preclinical translation through late-stage trials, partnering with Regulatory, Translational Medicine, and Biometrics teams to deliver safe, effective therapies.

The role emphasizes scientific leadership, cross-functional collaboration, and regulatory interactions, with a