Senior Clinical Pharmacology & PK/PD Lead

Eli Lilly and Company; United States; Remote; USD 168,000 - 268,000; Full time

Benefits offered by this job

401(k)

Pension

Vacation benefits

Health, dental, vision benefits

Flexible benefits

Life insurance

Well-being programs

Company bonus

Job summary

Centessa Pharmaceuticals, a Centessa subsidiary of Eli Lilly, seeks a senior clinical pharmacology/pharmacometrics expert to guide dose selection and study design for early-phase programs. You will integrate PK/PD, in vitro ADME, and biomarkers to support translational decisions and regulatory submissions.

You will lead PK/PD analyses, develop PBPK models, and interact with cross-functional teams to ensure rigorous pharmacology input into development plans.

Qualifications

• PhD or PharmD in Clinical Pharmacology, Pharmacokinetics, Pharmacometrics or related discipline (or graduate degree with strong work history).
• 3+ years of industry experience in clinical pharmacology/pharmacometrics in biotech/pharmaceutical drug development.

Responsibilities

• Provide clinical pharmacology and PK/PD input to project teams to inform dose, population, and study design.
• Conduct and interpret noncompartmental and population PK analyses for Phase 1–2 studies (FIH, SAD/MAD, DDI, food effect, organ impairment, patient studies).
• Build and apply exposure–response and PK/PD analyses and PBPK models to support dose selection and DDI risk assessment.
• Integrate nonclinical PK/PD, in vitro ADME, and biomarker data to support human PK and dose projections.
• Draft PK/PD sections of CDP, protocols, analysis plans, investigator brochures, study reports, and regulatory documents.
• Collaborate with DMPK, translational sciences, clinical development, bioanalysis, biostatistics, regulatory affairs, and project leadership.
• Provide day-to-day scientific oversight of CRO/vendor deliverables and participate in peer review of analyses and reports.
• Present findings to internal stakeholders and contribute to publications and presentations.

Skills

Communication skills

Pharmacetrics

PK/PD theory

Education

PhD or PharmD in Clinical Pharmacology or related

Tools

NONMEM

Phoenix WinNonlin

Monolix

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Job description

Centessa Pharmaceuticals, a Centessa subsidiary of Eli Lilly, seeks a senior clinical pharmacology/pharmacometrics expert to guide dose selection and study design for early-phase programs. You will integrate PK/PD, in vitro ADME, and biomarkers to support translational decisions and regulatory submissions.

You will lead PK/PD analyses, develop PBPK models, and interact with cross-functional teams to ensure rigorous pharmacology input into development plans.