Senior Clinical Operations Leader for Trials Oversight

PTC Therapeutics, Inc.; Philadelphia (Philadelphia County); On-site; USD 137,000 - 172,000; Full time

Benefits offered by this job

Incentives (short- and long-term)

Medical, dental, vision, and 401(k)

Job summary

PTC Therapeutics, Inc. is seeking a Senior Manager, Clinical Operations to oversee the planning, execution, and oversight of Phase I–IV trials across global sites. You will lead and mentor a team, ensure compliance with ICH-GCP, and manage timelines, budgets, and vendor relationships.

This role requires a bachelor’s degree in a scientific field and 7+ years of clinical research experience, with strong leadership, risk management, and cross-functional collaboration skills.

Qualifications

• Bachelor’s degree in a scientific discipline with 7+ years of clinical research experience.
• Experience leading clinical operations and cross-functional teams.
• Knowledge of ICH-GCP guidelines and global trial regulations.
• Willingness to travel ~20%.

Responsibilities

• Lead or support the operational execution of Phase I-IV clinical trials, depending on study complexity and program needs.
• Serve as Lead Clinical Trial Manager for assigned studies, with responsibility for study timelines, operational strategy, and study deliverables.
• Develop and manage key study documents, including Clinical Trial Management Plans and budgets.
• Oversee study start-up, conduct, and close-out activities.
• Provide oversight of CROs and service providers to ensure contract compliance and quality.
• Monitor study metrics and KPIs to ensure timelines and quality.
• Collaborate with Clinical Development, Data Management, Regulatory Affairs, and QA to align study plans.

Skills

ICH-GCP knowledge

Leadership

Project management

Vendor oversight

Communication

Risk management

Cross-functional collaboration

Education

Bachelor's degree in a scientific discipline

Tools

MS Office

Job description

PTC Therapeutics, Inc. is seeking a Senior Manager, Clinical Operations to oversee the planning, execution, and oversight of Phase I–IV trials across global sites. You will lead and mentor a team, ensure compliance with ICH-GCP, and manage timelines, budgets, and vendor relationships.

This role requires a bachelor’s degree in a scientific field and 7+ years of clinical research experience, with strong leadership, risk management, and cross-functional collaboration skills.