Senior Clinical Genomics Data Quality Reviewer

Grailbio; Durham (NC); On-site; USD 69,992 - 81,994; Full time

Job summary

GRAIL is seeking a Clinical Laboratory Specialist V to perform advanced post-analytical review of high-throughput clinical genomics data in a regulated CLIA/CAP lab. You will ensure data integrity and patient result quality prior to report release, with emphasis on sequencing metrics, assay performance, and regulatory compliance.

You will work on-site full-time in Durham, NC, collaborating with bioinformatics, quality, and reporting teams to maintain high standards and timely report

Qualifications

• Bachelor’s degree in a life science field with 3+ years in a high-complexity clinical lab.
• Experience with post-analytical data review, assay quality assessment, and clinical genomics workflows.
• Strong understanding of regulatory standards (CAP, CLIA, NYSDOH, ISO 15189).
• Proficiency with LIMS and quality management systems.

Responsibilities

• Perform comprehensive post-analytical review of clinical lab data before report release.
• Assess sequencing quality metrics, assay performance indicators, and pipeline outputs.
• Review batch- and sample-level data after bioinformatics processing for issues.
• Verify data quality and ensure documentation and quality checks are complete.
• Assess molecular assay performance across workflow stages (library prep, sequencing).
• Investigate data discrepancies and determine root causes and resolutions.
• Document findings in LIMS and quality systems with clear traceability.
• Collaborate with operations, bioinformatics, quality, and reporting teams.
• Contribute to quality monitoring, trend analysis, and improvement initiatives.
• Maintain compliance with CLIA/CAP, NYSDOH, ISO 15189, FDA requirements.

Skills

Post-analytical data review

Assay quality assessment

Clinical genomics workflows

Laboratory quality review

Molecular biology knowledge

Next-generation sequencing (NGS)

Regulatory compliance knowledge

LIMS proficiency

Quality systems

Data review platforms

multitasking

Regulated clinical lab operations

Education

Bachelor’s degree in life science

MB (ASCP) certification

Job description

GRAIL is seeking a Clinical Laboratory Specialist V to perform advanced post-analytical review of high-throughput clinical genomics data in a regulated CLIA/CAP lab. You will ensure data integrity and patient result quality prior to report release, with emphasis on sequencing metrics, assay performance, and regulatory compliance.

You will work on-site full-time in Durham, NC, collaborating with bioinformatics, quality, and reporting teams to maintain high standards and timely report