Senior Clinical Development Director - Rare Diseases

rhythmpharmaceuticals; Boston (MA); Hybrid; USD 230,000 - 330,000; Full time

Benefits offered by this job

Discretionary annual bonus

Restricted stock units (RSUs)

Benefits package

Job summary

Rhythm Pharmaceuticals seeks an Executive Medical Director to lead design, execution, and oversight of multiple clinical development programs (Phase 1–3) across rare neuroendocrine and genetic metabolic indications. You will guide strategy, regulatory submissions, and medical monitoring while collaborating with executive leaders and external networks.

The role is based in Boston with hybrid work expectations; you will mentor Medical Directors and drive high-impact scientific initiatives and

Qualifications

• MD or equivalent medical degree required; board certification in a clinical specialty preferred.
• 8–10 years of clinical development experience in pharma/biotech; leading global programs and regulatory interactions.
• Experience in rare disease, endocrinology, obesity, metabolic disease, pediatrics or related areas is strongly preferred.

Responsibilities

• Serve as Clinical/Medical Lead across multiple complex studies and development programs.
• Create, optimize, and execute Clinical Development Plans (CDPs) and innovative study protocols.
• Provide strategic medical leadership across cross-functional teams (Clinical Ops, Biostatistics, Data Management, Regulatory, Medical Affairs).
• Oversee medical monitoring activities and safety strategy; review aggregate safety data and SAE evaluations.
• Lead global regulatory filings (INDs, NDAs/BLAs/MAAs) and interactions with FDA/EMA/PMDA.
• Interpret complex clinical data and contribute to publications, congress presentations, and exec briefings.
• Mentor Medical Directors and study teams; foster knowledge sharing and leadership.

Skills

Leadership

Strategic mindset

Executive communication

Mentorship

KOL engagement

Cross-functional leadership

Education

MD or equivalent

Board certification in endocrinology/pediatrics/genetics/internal medicine or related

Job description

Rhythm Pharmaceuticals seeks an Executive Medical Director to lead design, execution, and oversight of multiple clinical development programs (Phase 1–3) across rare neuroendocrine and genetic metabolic indications. You will guide strategy, regulatory submissions, and medical monitoring while collaborating with executive leaders and external networks.

The role is based in Boston with hybrid work expectations; you will mentor Medical Directors and drive high-impact scientific initiatives and