Senior Cardiovascular NAMs Scientist - In Vitro Safety

BioSpace; Indianapolis (IN); Sur place; USD 126 000 - 205 000; Plein temps

Résumé du poste

Lilly in Indianapolis seeks a scientist to join the NAMs/CIVMs pillar within Investigative Toxicology. This individual contributor role sits in an integrated team delivering translational safety science across the drug discovery continuum.

Responsibilities include qualifying human-relevant in vitro models for cardiovascular liability (hiPSC-CMs, hiPSC-ECs, 3D EHTs), designing mechanistic studies, and integrating readouts like MEA, calcium imaging, and impedance.

Qualifications

• PhD with training in cardiac biology or cardiovascular electrophysiology.
• 2+ years postdoctoral or industry experience for Advisor level; 5+ years for Senior Advisor; hands-on work in advanced cardiovascular in vitro models.
• Experience with hiPSC-CMs, MEA-based proarrhythmia assessment, 3D EHT platforms, or endothelial/vessel-on-a-chip models.

Responsabilités

• Qualify and apply human-relevant in vitro cardiovascular models (hiPSC-CMs, hiPSC-ECs, 2D/3D systems).
• Design mechanistic studies into liabilities like proarrhythmia, QT prolongation, and endothelial dysfunction.
• Implement readouts: MEA, calcium imaging, contractility assays, impedance-based platforms.
• Develop 3D platforms (EHTs/COs) for chronic dosing and injury endpoints.
• Serve as scientific resource for in vitro investigations and CROs/academia partnerships.
• Collaborate with in silico teams to integrate data and build decision frameworks.

Connaissances

hiPSC-CMs

Endothelial cells

2D electrophysiology

3D EHTs

Cardiac organoids

Vessel-on-a-chip

MEA recordings

Calcium flux imaging

Sarcomere shortening

Impedance-based assays

CiPA paradigm

AI/ML imaging

Transcriptomic profiling

Formation

PhD in Pharmacology, Physiology, Biomedical Engineering, Toxicology, or related field

Description du poste

Lilly in Indianapolis seeks a scientist to join the NAMs/CIVMs pillar within Investigative Toxicology. This individual contributor role sits in an integrated team delivering translational safety science across the drug discovery continuum.

Responsibilities include qualifying human-relevant in vitro models for cardiovascular liability (hiPSC-CMs, hiPSC-ECs, 3D EHTs), designing mechanistic studies, and integrating readouts like MEA, calcium imaging, and impedance.