Senior Biotransformation Scientist - DMPK & IND Readiness

Socket.dev; San Diego (CA); On-site; USD 150,000 - 220,000; Full time

Benefits offered by this job

401k with company match

Medical, dental, vision insurance

Disability insurance

Bonus potential

Job summary

Vividion Therapeutics, Inc. is seeking a highly motivated Biotransformation expert to drive metabolite profiling and enzymology for drug discovery and development. The role covers in vitro and in vivo MetID, CRO oversight, and cross-functional collaboration to support IND efforts.

The candidate will interpret mass spectra, prepare data summaries, and contribute to regulatory documents while mentoring the in-house DMPK team.

Qualifications

• PhD in Organic Chemistry, Drug Metabolism, Pharmacokinetics, Pharmaceutical Sciences, or related discipline with 7+ years of industry experience; MS/BS with 12+ years’ experience will be considered.
• Expertise in drug metabolism, in vitro enzyme kinetics, ADME assays and LC/MS bioanalytical methodology.
• Experience in designing, executing and reviewing biotransformation studies.
• Understanding of regulatory guidance including MIST.
• Experience in biotransformation document preparation for regulatory submissions is a plus.]

Responsibilities

• Design and conduct non-labeled and radiolabeled in vitro and in vivo biotransformation studies.
• Execute in vitro soft-spot and tox species selection MetID studies and conduct in vivo MetID studies.
• Manage and provide oversight for biotransformation studies conducted at CROs.
• Interact with multidisciplinary project teams.
• Lead DMPK studies supporting preclinical and clinical development.
• Author regulatory submission documentation including IND summaries and Investigator Brochure.

Skills

Data-driven analysis

Lead cross-functional teams

Technical communication

Autonomous contributor

DMPK & enzymology

Education

PhD in Organic Chemistry/Drug Metabolism/Pharmacokinetics/Pharmaceutical Sciences

MS/BS with 12+ years industry experience

Tools

LC-MS

Job description

Vividion Therapeutics, Inc. is seeking a highly motivated Biotransformation expert to drive metabolite profiling and enzymology for drug discovery and development. The role covers in vitro and in vivo MetID, CRO oversight, and cross-functional collaboration to support IND efforts.

The candidate will interpret mass spectra, prepare data summaries, and contribute to regulatory documents while mentoring the in-house DMPK team.