Senior Biostatistics Programmer - Hybrid Boston

rhythmpharmaceuticals; Boston (MA); Hybrid; USD 90,000 - 135,000; Full time

Job summary

Rhythm Pharmaceuticals, based in Boston, seeks a Senior Statistical Programmer to join the Biostatistics and Statistical Programming team. The role delivers analysis datasets, tables, listings, and figures for studies and submissions, collaborates across functions, and may mentor junior programmers.

Responsibilities include developing ADaM specs, SDTM, define.xml, and aiding regulatory readiness. The role is hybrid with some travel, salary range $90,000–$135,000, plus discretionary bonus and

Qualifications

• MS or equivalent degree in Statistics, Biostatistics, Mathematics, Computer Science, or a related discipline; advanced degree preferred.
• 3+ years relevant statistical programming experience in biotech, pharma, or CRO settings; vendor oversight experience preferred but not required.
• Strong hands‑on SAS programming expertise including Base SAS, SAS/STAT, SAS/GRAPH, SAS/SQL, SAS/ODS, and macro development; experience with R or other modern tools is a plus.

Responsibilities

• Lead or support statistical programming activities for assigned clinical studies, including development, validation, and quality control of analysis datasets, tables, listings, and figures for study reports, regulatory submissions, and internal decision‑making.
• Serve as a study lead programmer or programming representative, partnering with Biostatistics, Data Management, Clinical Development, Medical Writing, Regulatory, and external vendors to deliver high‑quality results on time.
• Develop, review, and maintain ADaM specifications, TLF shells, programming documentation, reusable macros, and study‑level programming standards in alignment with company procedures and regulatory expectations.
• Provide input into protocols, statistical analysis plans, CRF design and annotation, edit checks, SDTM specifications, integrated data review, and submission strategy to ensure traceability, consistency, and efficient downstream analysis.
• Support regulatory submission readiness, including preparation and review of define.xml, reviewer guides, submission‑ready datasets, and related documentation in compliance with CDISC and global regulatory requirements.
• Identify programming risks, drive issue resolution, and recommend process improvements that enhance quality, scalability, efficiency, and inspection readiness across studies and programs.
• Depending on level, mentor junior programmers, provide technical guidance, contribute to resource planning, oversee vendor deliverables, and help shape departmental standards, tools, and best practices.

Skills

SAS programming

CDISC standards

Clinical data analysis

Regulatory submissions

Mentoring programmers

Education

MS or equivalent in Statistics/Biostatistics/CS

Advanced degree preferred

Tools

SAS

R

Job description

Rhythm Pharmaceuticals, based in Boston, seeks a Senior Statistical Programmer to join the Biostatistics and Statistical Programming team. The role delivers analysis datasets, tables, listings, and figures for studies and submissions, collaborates across functions, and may mentor junior programmers.

Responsibilities include developing ADaM specs, SDTM, define.xml, and aiding regulatory readiness. The role is hybrid with some travel, salary range $90,000–$135,000, plus discretionary bonus and