Senior Biophysical/Analytical Scientist, Biotherapeutics

100 Eli Lilly and Company; Indianapolis (IN); On-site; USD 129,000 - 211,000; Full time

Benefits offered by this job

401(k)

Pension

Vacation benefits

Medical, dental, vision

Flexible benefits

Life insurance

Time off and leave

Job summary

Lilly in Indianapolis seeks a Biophysical/Analytical Scientist to lead characterization of biotherapeutics across diverse modalities, partnering with R&D teams to inform developability and formulation decisions.

Requires deep expertise in biophysical methods, experience with binding kinetics platforms, and a collaborative mindset; the role offers strong project exposure and opportunities to advance drug candidates.

Qualifications

• Ph.D. in biochemistry, biotechnology, analytical chemistry, chemical engineering, pharmaceutical sciences, or a related field with at least 2 years of industry experience.
• M.S. with at least 7 years of relevant industry experience.

Responsibilities

• Serve as the primary biophysical/analytical point-of-contact for assigned programs, independently driving strategic decisions and partnering directly with project and platform teams on developability, characterization, and formulation-related questions.
• Collaborate with protein engineers, medicinal chemists, preclinical biologists, ADME scientists, and other stakeholders to use characterization data to inform SAR and risk assessment.
• Apply deep biophysical and analytical expertise flexibly across diverse and complex modalities as project and platform needs evolve.
• Execute and interpret orthogonal biophysical and analytical characterization across RP-HPLC, aSEC, HILIC, IEX, CE-SDS, cIEF, nanoDSF, CD, SoloVPE, SLS, SEC-MALS, DLS, CG-MALS, ITC, DSC, SPR, Octet to support developability and candidate selection decisions.
• Apply computational or structure-based modeling methods (e.g., Schrödinger, MOE, molecular dynamics) to complement biophysical data and inform candidate selection decisions.
• Apply statistical analysis using software such as JMP or Prism to evaluate experimental data and support data-driven decisions.
• Search and review relevant scientific literature and the external environment to identify innovation opportunities and best practices applicable to biophysical and analytical characterization.
• Accurately document experimental procedures and communicate results via presentations, written reports, and electronic notebooks following established procedures.

Job description

Lilly in Indianapolis seeks a Biophysical/Analytical Scientist to lead characterization of biotherapeutics across diverse modalities, partnering with R&D teams to inform developability and formulation decisions.

Requires deep expertise in biophysical methods, experience with binding kinetics platforms, and a collaborative mindset; the role offers strong project exposure and opportunities to advance drug candidates.