Senior Biologics Scientist - Antibody Engineering

Broad Institute; Cambridge (MA); On-site; USD 120,000 - 190,000; Full time

Benefits offered by this job

Medical, dental, vision benefits

401(k) retirement plan

Generous paid holidays and time off

Job summary

The Broad Institute is seeking a Senior Research Scientist I to join the Center for the Development of Therapeutics (CDoT) Biologics team in Cambridge. Lead antibody engineering campaigns from concept to lead identification and work across formats including multispecific antibodies.

You will design and execute engineering workflows, characterize candidates with biochemical/biophysical assays, and collaborate with industry and academic partners to advance drug discovery programs.

Qualifications

• PhD with 5+ years post-PhD industry experience in biologics drug discovery.
• Deep antibody biology, structure-function, and optimization expertise.
• Experience with complex biologics formats, such as T cell engagers, TCR engagers, bispecific or multispecific antibodies, ADCs, CAR-T or immunocytokine fusions is essential.
• Hands-on experience with structure-guided engineering of antibodies and modeling software to optimize biophysical properties and developability.
• Proven ability to design, manage and evaluate outsourced biologics workflows at CROs and manage multiple projects.

Responsibilities

• Lead integrated antibody and biologics engineering campaigns from concept through lead identification and optimization.
• Design, execute, and oversee antibody engineering workflows, including affinity maturation, humanization, format conversion, Fc engineering, expression, purification, and characterization.
• Engineer and evaluate antibodies across multiple therapeutic formats, including IgG, Fab, scFv, bispecific or multispecific antibodies, T cell engagers, TCR engagers, CAR-T formats.
• Characterize antibody candidates using biochemical, biophysical, and functional assays to assess binding, affinity, specificity, epitope diversity, developability, potency, and mechanism of action.
• Collaborate with industry and academic partners and other CDoT team members on cross-functional projects.

Skills

Antibody biology

Antibody structure

Biologics optimization

Discovery platforms

Developability

CRO management

Biophysics assays

Education

PhD in immunology, molecular biology, biochemistry, protein engineering, or related discipline

Tools

Schrodinger

MOE

PyMOL

Biacore

Carterra

Octet

ELISA

HPLC

DLS/SLS

Job description

The Broad Institute is seeking a Senior Research Scientist I to join the Center for the Development of Therapeutics (CDoT) Biologics team in Cambridge. Lead antibody engineering campaigns from concept to lead identification and work across formats including multispecific antibodies.

You will design and execute engineering workflows, characterize candidates with biochemical/biophysical assays, and collaborate with industry and academic partners to advance drug discovery programs.