Senior Biologics Purification Scientist (DOE & Automation)

BioSpace; North Chicago (IL); On-site; USD 120,000 - 170,000; Full time

Benefits offered by this job

Benefits package

Job summary

AbbVie’s Biologics Discovery Sciences group seeks a scientist specializing in Biologics Purification to drive drug discovery and deliver high-purity multi-specific antibody biologics for in vitro and in vivo studies worldwide.

You will lead purification design, analytics, and DOE-driven optimization, collaborating across multidisciplinary teams and presenting findings with clarity. Strong communication, scientific excellence, and a patient-centric mindset are essential.

Qualifications

• BS/MS/PhD in Bioinformatics, Biophysics, Chemical Engineering or related field with typically 8-10 years (BS), 5-7 years (MS), or 0-3 years (PhD) of experience.
• Deep proficiency in bioprocessing, column chromatography, and antibody-based biotherapeutics manufacturing.
• Expertise with AKTA chromatography systems.
• Experience operating high throughput automated liquid handling systems for chromatography applications (i.e. Tecan, Hamilton) is desirable.
• DOE studies with protein production scale-up experience is preferable.
• Familiarity with programming languages (Python) and developing Bioinformatics or AI/ML tools is a plus.
• Strong understanding of molecular and post-translational attributes of biologics.
• Exceptional analytical, communication, and presentation skills.
• Collaborative spirit and dedication to scientific excellence.

Responsibilities

• Lead small-scale (<1L) purification of multi-specific antibody biologics to support critical research assays and studies.
• Design and execute advanced chromatography techniques and robust bioprocess development strategies to address production impurities and liabilities to deliver high quality antibody biologics to therapeutic areas.
• Execute rigorous analytical characterization of molecules, end products, by-products, and process intermediates.
• Apply Design of Experiments (DOE) with high throughput automation to optimize chromatography conditions for enhanced separation and resolution of complex protein mixtures.
• Drive innovation to support continuous improvement in downstream biologics processes and advance automation initiatives.
• Collaborate with multidisciplinary teams, translating molecular insights into functional results.
• Present findings clearly to diverse audiences and document results with rigor.

Skills

Bioprocessing

Column chromatography

AKTA chromatography

DOE studies

High-throughput automation

Python

Analytical skills

Education

Bioinformatics / Biophysics / Chemical Engineering degree

Tools

AKTA systems

Tecan automation

Hamilton robotics

Robocolumns

Job description

AbbVie’s Biologics Discovery Sciences group seeks a scientist specializing in Biologics Purification to drive drug discovery and deliver high-purity multi-specific antibody biologics for in vitro and in vivo studies worldwide.

You will lead purification design, analytics, and DOE-driven optimization, collaborating across multidisciplinary teams and presenting findings with clarity. Strong communication, scientific excellence, and a patient-centric mindset are essential.