Scientist/Sr. Scientist-Preclinical Antibody Drug Development

Biocytogen Pharmaceuticals Co.; Waltham (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Medical Insurance

Dental Insurance

Vision Insurance

Health Reimbursement Accounts

Life and AD&D Insurance

Short & Long Term Disability Insurance

401K with Company Match

Paid Time Off

Paid Sick Days & Holidays

Job summary

Biocytogen is seeking highly skilled and motivated scientists to join our antibody discovery team. This role focuses on optimizing therapeutic antibody binders from our RenBiologics program, using advanced engineering to improve affinity, specificity, stability, and developability across multiple disease areas.

You will lead design of experiments, manage projects with cross-functional teams, and present findings to internal and external stakeholders as we advance assets toward preclinical

Qualifications

• PhD in Biochemistry, Molecular Biology, Immunology, or related field.
• 2+ years antibody engineering and project management experience.
• Strong MOA, druggability, and formulation knowledge.
• Proven ability to drive projects and meet milestones.
• Excellent collaboration and communication skills.

Responsibilities

• Select and evaluate therapeutic targets with MOA, druggability and delivery options.
• Design strategies to advance candidates toward therapeutic development.
• Drive projects by assembling resources, managing timelines and alignment.
• Engineer antibodies to improve affinity, specificity, stability and manufacturability.
• Optimize antibodies via advanced molecular designs (Fc engineering, bispecifics).
• Evaluate lead antibodies for binding, function and developability for preclinical readiness.
• Collaborate with discovery, manufacturing and licensing teams; present findings.

Skills

Antibody engineering

Project management

Cross-functional collaboration

Target biology research

Education

PhD in Biochemistry/Molecular Biology/Immunology

MS with 5+ years antibody engineering

Job description

Biocytogen is seeking highly skilled and motivated scientists to join our antibody discovery team. This role is dedicated to optimizing therapeutic antibody binders from our RenBiologics program, which generates an extensive library of therapeutic antibodies targeting thousands of druggable genes. The successful candidate will utilize advanced antibody engineering techniques to improve binding affinity, specificity, stability, and therapeutic functionality. This work supports the development of antibodies across diverse therapeutic areas, including immuno-oncology, inflammatory and autoimmune diseases, neurology, cardiovascular conditions, and metabolic disorders.

Key Responsibilities

Target Selection and Program Design

• Select and evaluate therapeutic targets with a strong understanding of MOA, druggability, and delivery options
• Design experimental strategies to advance candidates from Biocytogen's RenBiologics Antibody Binder/Lead Library toward therapeutic development

Project Management

• Drive projects by assembling resources, managing timelines, and ensuring alignment with program objectives

Antibody Engineering and Optimization

• Engineer antibodies to improve affinity, specificity, stability, and manufacturability
• Optimize antibodies through advanced molecular designs, such as Fc engineering or bispecific formats

Lead Evaluation and Development

• Evaluate lead antibodies for binding, function, and developability, ensuring readiness for preclinical development

Collaboration and Reporting

• Work with discovery, manufacturing, and BD licensing teams to advance and out-license antibody assets
• Maintain clear documentation and present findings to internal and external stakeholders

Requirements

• PhD in Biochemistry, Molecular Biology, Immunology, or a related field with 2+ years of relevant experience, or MS with 5+ years of experience in antibody engineering and project management
• Strong expertise in target biology research, including understanding MOA, druggability, and formulation requirements
• Proven experience in antibody engineering and optimization, including affinity maturation and stability improvement
• Demonstrated ability to independently drive projects, assemble resources, and meet critical milestones
• Excellent collaboration and communication skills for working with cross-functional teams and presenting findings effectively

Benefits

• Medical Insurance
• Dental Insurance
• Vision Insurance
• Health Reimbursement Accounts
• Life and AD&D Insurance
• Short & Long Term Disability Insurance
• 401K with Company Match
• Paid Time Off
• Paid Sick Days & Holidays

BIOCYTOGEN is an Equal Opportunity Employer. Employment opportunities at BIOCYTOGEN BOSTON CORP are based upon one's qualifications and capabilities to perform the essential functions of a particular job. All employment opportunities are provided without regard to race, color religion, sex, national origin, ancestry, age, sexual orientation, gender identity and expression, veteran status, military status, disability, mental illness, genetic information, or any other characteristic protected by law. This Equal Employment Opportunity policy governs all aspects of employment, including, but not limited to, recruitment, hiring, selection, job assignment, promotions, transfers, compensation, discipline, termination, layoff, access to benefits and training, and all other conditions and privileges of employment.