Senior Associate Scientist, Neuroscience Translational Discovery

Bristol-Myers Squibb; Cambridge (MA); On-site; USD 80,000 - 110,000; Full time

Job summary

An established industry player is seeking a Senior Associate Scientist in Translational Discovery to join their Neuroscience Thematic Research Center. This laboratory-based role involves developing biomarker assays, managing specimens, and preparing data packages to support drug candidates in clinical trials. You will collaborate with high-achieving teams to drive innovative research in neurodegenerative and neuropsychiatric diseases. This position offers a unique opportunity to contribute to meaningful work that transforms patient lives while enjoying a supportive work environment that values balance and flexibility.

Benefits

Competitive benefits

Flexible work environment

Opportunities for career growth

Collaborative teams

Qualifications

• 4+ years of experience with a Bachelor’s or 2+ years with a Master’s.
• Hands-on experience in immunoassays and molecular assays is preferred.

Responsibilities

• Develop biomarker assays and manage TRC specimens for development.
• Prepare data packages for phase 1 studies and present scientific data.

Skills

Immunoassays

Molecular assays

Data analysis

Communication skills

Independent work

Education

Bachelor’s Degree

Master’s Degree

Tools

ELISA

qPCR

RNAseq

Job description

Working with Us
Challenging. Meaningful. Life-changing. Those aren’t words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You’ll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuropsychiatric and neuromuscular diseases. A network of external partnerships paired with internal discovery of small molecules, biologics and genetic medicines supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology linking the immune system, protein clearance and synaptic mechanisms with nervous system disorders, applying human cells, AI, ML and high-throughput biology to identify and validate novel mechanisms.

Areas of interest include, but are not limited to, the identification of disease modifying and symptomatic therapies for neurodegenerative, neuropsychiatric, neuroinflammatory and neuromuscular diseases; approaches to modulate protein clearance and reduce or eliminate toxic protein production; emerging technologies (RNA, DNA targeting) that when matched to underlying causal human biology may deliver a precision medicine portfolio with a high probability of translational success. We emphasize identification of neuroimaging and fluid biomarkers to track disease progression, target engagement and therapeutic response in our discovery and clinical programs.

Position Summary:

The Neuroscience Thematic Research Center (Neuro TRC) leverages external collaborations and internal research to establish a diverse portfolio targeting unmet needs in neurodegenerative, neuropsychiatric, neuroinflammatory and neuromuscular diseases. The Senior Associate Scientist, Translational Discovery, in collaboration with other members of the Neuro TRC, undertakes design and delivery of translational data packages that enable rapid progression of drug candidates towards clinical proof-of-concept. This position is based in Cambridge, MA, and is primarily a laboratory-based role.

Position Responsibilities:

• Work closely with the team to develop target engagement and biomarker assays for assets in early development.
• Drive biomarker assay qualification with CROs.
• In collaboration with Global Biospecimen Inventory Management, manage TRC specimens for target engagement and biomarker development.
• Prepare data packages to support target engagement and biomarker data inclusion for phase 1 studies.
• Work closely, in collaboration with in-house science teams, on study designs, data analyses, interpretation that support high priority neuro projects/programs.
• Draft and review internal project reports as needed; present scientific data at internal and external conferences.

Basic Qualifications:

• Bachelor’s Degree with 4+ years of academic and/or industry experience.
• Or Master’s Degree with 2+ years of academic and/or industry experience.

Preferred Qualifications:

• Hands-on experience in immunoassay and molecular assays (ELISA, Meso-scale discovery, SIMOA, qPCR, dd-PCR, RNAseq, etc.).
• Experience in managing biorepositories.
• Proven track record in designing, troubleshooting, analyzing and interpreting data from translational and experimental medicine type studies.
• Experience transferring assay to contract research organizations for analysis in multi-site clinical trials.
• Deep understanding of unmet need and clinical outcome measures used in studies focused on neurodegenerative disorders.
• Excellent oral and written communication skills.
• Ability to work both independently and as a well-integrated member of multidisciplinary drug development teams.