Senior Associate Scientist, In Vivo Pharmacology

Bristol-Myers Squibb Company; Cambridge (MA); On-site; USD 80,000 - 120,000; Full time

Job summary

An innovative biopharma company is seeking a Senior Associate Scientist to join their Neuroscience TRC. This role offers the chance to work on transformative therapeutics for neurodegenerative diseases, leveraging cutting-edge technologies and collaborations. You'll be part of a dynamic team, conducting in vivo studies to propel drug candidates from concept to clinical proof. With a focus on enhancing CNS delivery, this position promises a fulfilling career path in a supportive and inclusive environment, where your contributions can significantly impact patient lives.

Benefits

Flexible work environment

Competitive benefits

Professional development opportunities

Health and safety protocols

Qualifications

• 4+ years in drug discovery research with emphasis on CNS delivery.
• Hands-on experience in in vivo pharmacology and animal model handling.

Responsibilities

• Implement studies for novel BBB delivery technologies.
• Maintain transgenic models for drug candidate evaluation.

Skills

In vivo pharmacology

Animal model handling

Drug discovery research

Communication skills

Collaboration with external partners

Education

Bachelor's Degree

Master's Degree

Tools

Genetically modified animals

Blood-brain-barrier delivery technologies

Job description

Working with Us

Challenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams. Take your career farther than you thought possible.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more: careers.bms.com/working-with-us.

When you join BMS, you are joining a diverse, high-achieving team united by a common mission.

The Neuroscience TRC is committed to the development of transformational therapeutics for patients with neurodegenerative, neuromuscular and neuropsychiatric diseases. A network of internal and external partnerships across neurodegenerative and neuropsychiatric diseases and treatment modalities (small molecules, biologics and genetic medicines) supports our ambition to become leaders in neuroscience. Internal research focuses on causal human biology, matching therapeutic modality to molecular mechanism, and translational discovery enabling a rapid path to clinical proof-of-concept.

Areas of interest include, but are not limited to, the identification of disease modifying and symptomatic therapies for neurodegenerative, neuro-inflammatory neuropsychiatric and neuromuscular diseases; approaches to modulate protein clearance and reduce or eliminate toxic protein production; emerging technologies (RNA, DNA targeting) that when matched to underlying causal human biology may deliver a precision medicine portfolio with a high probability of translational success; AI/ML in target identification drug discovery; neuroimaging and fluid biomarkers to track disease progression and target engagement; novel blood brain-barrier technologies to enhance delivery of biotherapeutics and genetic medicines across the blood-brain barrier.

Here, you'll get the chance to grow and thrive through uncommon opportunities and scope. You'll pursue innovative ideas while advancing professionally alongside some of the brightest minds in biopharma.

Position Summary:

The Neuroscience Thematic Research Center (Neuro TRC) leverages external collaborations and internal research to establish a diverse portfolio targeting unmet needs in neurodegenerative, neuropsychiatric, neuroinflammatory and neuromuscular diseases. The Senior Associate Scientist, Neuroscience Discovery, in collaboration with other members of the Neuroscience TRC, implements in vivo studies that enable rapid progression of drug candidates from target identification through clinical proof-of-concept. This laboratory-based role is based in Cambridge, MA, and will join a team of scientists responsible for supporting our collaborative drug discovery mission.

Position Responsibilities:

• Implement studies designed to evaluate novel BBB delivery technologies and therapeutic modalities applied to diseases of strategic interest to the Neuroscience TRC
• Maintain and integrate transgenic and other animal models to evaluate and select drug candidates for further investment
• Support programs employing novel delivery technologies for neurodegenerative and neuromuscular disorders

Basic Qualifications:

• Bachelor's Degree with 4+ years of academic and/or industry experience

Or

• Master's Degree with 2+ years of academic and/or industry experience

Preferred Qualifications:

• BA, BS or MS with 4+ years of experience in drug discovery research spanning small molecule, biotherapeutics, and genetic medicines discovery, with an emphasis on evaluating novel delivery technologies and approaches to enhance CNS delivery of therapeutic agents, using genetically modified animals where appropriate
• Hands-on experience in in vivo pharmacology, including small animal handling, surgical techniques, maintenance and breeding of transgenic animal colonies, and coordination of research activities with external partners and vendors
• Experience working as part of an interdisciplinary drug discovery team
• Experience creating and applying genetically engineered animal models of neurologic disease towards identification of novel therapeutics
• Experience leading drug discovery programs from ideation to delivery of a therapeutic candidate
• Expertise in blood-brain-barrier delivery technologies spanning bi-specific antibodies and genetic medicines
• Experience contributing to external collaborations and partnerships
• Excellent oral and written communication skills
• Ability to work both independently and as part of multidisciplinary teams

#LI-Onsite

If you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Uniquely Interesting Work, Life-changing Careers

With a single vision as inspiring as "Transforming patients' lives through science", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our talents and perspectives in a supportive culture, promoting global participation in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion, and integrity bring out the highest potential of each of our colleagues.

On-site Protocol

BMS has an occupancy structure that determines where an employee is required to work. This includes site-essential, site-by-design, field-based, and remote-by-design roles. The assigned occupancy type depends on your role's nature and responsibilities:

• Site-essential roles require 100% onsite work
• Site-by-design roles may be eligible for a hybrid model with at least 50% onsite
• Field-based and remote roles require travel and attendance at meetings as directed

BMS is committed to accessibility and accommodations. Applicants can request reasonable workplace adjustments prior to accepting an offer. For accommodations, contact [e-mail]. Visit careers.bms.com/eeo-accessibility for our EEO statement.

We prioritize health and safety, recommending full Covid-19 vaccination and boosters.

BMS considers qualified applicants with arrest and conviction records, pursuant to applicable laws.

If you live or work in Los Angeles County, additional information is available at https://careers.bms.com/california-residents/.

All data in the application process will be handled per privacy policies and regulations.