Senior Associate Scientist, Mass Spec Assay Development

Regeneron Pharmaceuticals; Tarrytown (GA); On-site; USD 80,000 - 131,000; Full time

Job summary

Regeneron Pharmaceuticals in Tarrytown, NY is seeking a Senior Associate Scientist in the Assay Development Group. You will develop and optimize mass spectrometry–based methods to quantify biologics, siRNAs, and antibody conjugates, generating high-quality data for programs across the pipeline.

The role involves hands-on MS/HPLC work, data interpretation, and collaboration with CROs and cross-functional teams. Strong emphasis on GLP practices and FDA-aligned documentation is required.

Qualifications

• Bachelor’s or Master’s degree in Biophysics, Biochemistry, Chemistry, Engineering, or a related field with 3–6 years of industry experience.
• Ability to independently design experiments, analyze data, and communicate findings to cross-functional teams.
• Hands-on experience operating and troubleshooting HPLC/UHPLC and MS instrumentation (QQQ, Q-TOF, Orbitrap).
• Strong initiative, scientific curiosity, organization, and ability to prioritize multiple projects with minimal supervision.
• Excellent oral and written communication skills with compliant laboratory documentation.
• Preferred: experience in PK/PD and large molecule bioanalysis; KingFisher and automated sample prep experience.

Responsibilities

• Optimize, troubleshoot, and execute quantitative MS assays for biomarkers, proteins, peptides, siRNAs, antibody conjugates, small molecules, and linkers.
• Perform hands-on lab work using HPLC/UHPLC, MS, KingFisher purification/extraction, and related quantitation methods.
• Analyze and interpret complex datasets; maintain ELN records; present findings to technical and cross-functional audiences.
• Manage multiple assays/projects and evaluate emerging technologies and formats.
• Maintain GLP-compliant practices and FDA-aligned documentation for assay validations.
• Collaborate with Bioanalytical Sciences, Regeneron, and CROs to support program execution.

Skills

Experiment design

Data interpretation

Cross-functional collaboration

Communication skills

Education

Bachelor's or Master's in Biophysics/Biochemistry/Chemistry/Engineering

Tools

Mass spectrometry

HPLC/UHPLC

KingFisher systems

Job description

Regeneron Pharmaceuticals in Tarrytown, NY is seeking a Senior Associate Scientist in the Assay Development Group. You will develop and optimize mass spectrometry–based methods to quantify biologics, siRNAs, and antibody conjugates, generating high-quality data for programs across the pipeline.

The role involves hands-on MS/HPLC work, data interpretation, and collaboration with CROs and cross-functional teams. Strong emphasis on GLP practices and FDA-aligned documentation is required.