Senior Analytical Scientist, Process Excellence (Hybrid)

Vertex Pharmaceuticals Incorporated; Boston (MA); Hybrid; USD 120,000 - 180,000; Full time

Benefits offered by this job

Hybrid-Eligible

On-Site Eligible

Annual bonus

Equity awards

Commuting subsidy

Job summary

Vertex Pharmaceuticals Incorporated seeks an experienced analytical chemist for late-stage product development in a commercial setting. You will collaborate with CMOs and Vertex scientists to solve analytical challenges, develop and troubleshoot methods, and drive continuous improvement using Quality by Design principles.

The role emphasizes cross-functional coordination, data-driven decision making, and effective communication to support commercial drug product manufacturing and process

Qualifications

• Experience in analytical development or technical operations supporting new product development or commercialization.
• Problem-solving/root cause analysis for analytical issues.
• Experience with chromatography methods (HPLC, GC) and analytical techniques.
• Knowledge of compendial methods for analysis (e.g., KF, elemental impurity testing, spectroscopy).
• cGMP/ICH knowledge in a pharmaceutical setting.
• Proficient with data analytics and visualization tools.
• Strong written and verbal communication skills.
• Ability to work in matrix and independent settings.
• Experience managing projects and adapting to changing priorities.

Responsibilities

• Manage method transfers for small molecule drug product and intermediates to CMOs for late-phase and commercial projects.
• Author/review documentation for methods, SOPs, transfer protocols/reports, and technical reports.
• Oversee commercial QC testing at Vertex's Contract Testing Organizations.
• Review analytical data from QC release and stability studies.
• Lead analytical OOS/OOT investigations and assist process investigations.
• Perform statistical analysis for continued process verification.
• Coordinate with MS&T, Supply Chain, Quality, and Regulatory on manufacturing activities.
• Manage analytical method lifecycle including performance trending and change control.

Skills

HPLC

GC

Data analytics

cGMP knowledge

Communication skills

Teamwork

Statistical analysis

Process improvement

Education

PhD

MS

BS

Job description

Vertex Pharmaceuticals Incorporated seeks an experienced analytical chemist for late-stage product development in a commercial setting. You will collaborate with CMOs and Vertex scientists to solve analytical challenges, develop and troubleshoot methods, and drive continuous improvement using Quality by Design principles.

The role emphasizes cross-functional coordination, data-driven decision making, and effective communication to support commercial drug product manufacturing and process