Senior Analytical Scientist, Process Excellence

Vertex Pharmaceuticals Inc (US); Boston (MA); Hybrid; USD 120,000 - 180,000; Full time

Job summary

Vertex is seeking a talented analytical chemist for late-stage product development in a commercial setting, with emphasis on Process Excellence, working with CMOs and a diverse team of scientists in a global organization. You will develop, implement and troubleshoot analytical methods in pharmaceutical production, influencing colleagues with strong communication and negotiation skills.

The role requires experience in method transfers, data analysis, and process verification, in a collaborative,

Qualifications

• Bachelor's, Master's, or PhD in Chemistry, Chemical Engineering, Pharmaceutical Chemistry, or related natural science.
• Experience developing analytical methods and transferring to CMOs.
• Knowledge of cGMPs, ICH guidelines, and CMC regulatory considerations.

Responsibilities

• Manage method transfers for small molecule drug product and drug product intermediate to CMOs.
• Author/review documentation to support commercial products.
• Manage commercial QC testing at Vertex’s Contract Testing Organizations.
• Conduct technical review of analytical data (QC release and stability testing).
• Lead analytical OOS/OOT investigations and assist process investigations.
• Perform statistical analysis for continued process verification.
• Coordinate with MS&T, Supply Chain, Quality, and Regulatory to support manufacturing.
• Manage analytical method lifecycle (method performance trending, process improvement, change control).

Skills

Analytical chemistry

Root cause analysis

HPLC/GC

cGMP knowledge

Data analytics

Technical writing

Team collaboration

Education

Bachelor's/Master's/PhD in Chemistry or related field

Job description

Vertex is seeking a talented analytical chemist for late-stage product development in a commercial setting, with emphasis on Process Excellence, working with CMOs and a diverse team of scientists in a global organization. You will develop, implement and troubleshoot analytical methods in pharmaceutical production, influencing colleagues with strong communication and negotiation skills.

The role requires experience in method transfers, data analysis, and process verification, in a collaborative,