Senior AI & Knowledge Platform Architect

Osprey Life Sciences; Boston (MA); On-site; USD 180,000 - 240,000; Full time

Job summary

Osprey Life Sciences, LLC is seeking a hands-on Technical Architect to lead an AI-assisted knowledge platform initiative. You will own end-to-end architecture across ingestion, knowledge graph, and LLM grounding, evaluating platforms and driving prototyping, architecture validation, and code reviews.

You will define canonical data models for medical claims, ensure provenance, and guide decisions on tooling and standards.

Qualifications

• 10+ years of experience designing data, knowledge, integration, or information-platform architectures.
• Hands-on experience with AI/LLM-enabled solutions and knowledge graphs.
• Experience with RDF, SPARQL, and ontology modeling.

Responsibilities

• Define the end-to-end architecture for AI-assisted claim acquisition, extraction, knowledge modeling, graph storage, and LLM grounding and verification.
• Evaluate and recommend knowledge graph and semantic technology platforms (e.g., Semaphore, MANTIS, System Graph).
• Define the canonical data model for medical claims, supporting evidence, citations, and provenance.
• Assess LLM access strategies including AWS Bedrock and API access.
• Develop cost, performance, security, and token-management analyses to support platform decisions.
• Design the MCP server and LLM interface layer with authentication, authorization, auditing, and usage instrumentation.
• Establish standards for claim versioning, data lineage, provenance tracking, and semantic interoperability.
• Determine where FHIR, schema.org, or related semantic frameworks may be appropriate.
• Provide architectural guidance to the Technical Lead and engineering teams.
• Contribute to prototypes, code reviews, and technical validation.
• Prepare executive decision packages with platform recommendations.

Skills

Data architecture

AI/LLM architectures

Knowledge graphs

API design

Prototyping

Communication

Stakeholder collaboration

AWS Bedrock

Cost-performance analysis

Security & auth

Tools

RDF

SPARQL

Ontology modeling

MarkLogic

MANTIS

Semaphore

System Graph

Job description

Osprey Life Sciences, LLC is seeking a hands-on Technical Architect to lead an AI-assisted knowledge platform initiative. You will own end-to-end architecture across ingestion, knowledge graph, and LLM grounding, evaluating platforms and driving prototyping, architecture validation, and code reviews.

You will define canonical data models for medical claims, ensure provenance, and guide decisions on tooling and standards.