Scientist (Viral Vector Process Development)

Tailored Management; San Francisco (CA); On-site; USD 50,000 - 66,000; Full time

Benefits offered by this job

Weekly pay

Medical, dental, vision, disability

Job summary

Tailored Management in South San Francisco is seeking a Scientist II to support LVV and AAV production platforms, focusing on improving viral vector yield, throughput, and quality to support research and pipeline development.

The role requires a MS/PhD in a relevant field and at least 3 years of lab experience, with hands-on ex vivo CAR-T cell engineering using lentiviral vectors. DOE, QC, and cross-functional collaboration are essential.

Qualifications

• MS or PhD in Cell Biology, Molecular Biology, Virology, Biochemistry, Bioengineering, Genetics, or a related field.
• At least 3 years of laboratory research or industry experience.
• Hands-on experience with ex vivo CAR-T cell engineering using lentiviral vectors.
• Proficiency in mammalian cell culture, transient transfection, and molecular biology techniques, such as PCR, qPCR, ddPCR, dPCR, or Western blot.
• Strong analytical, data interpretation, documentation, and communication skills.

Responsibilities

• Develop and optimize LVV and AAV production workflows using automated systems and parallel bioreactor platforms.
• Perform mammalian cell culture, transient transfection, viral vector production, and upstream process optimization.
• Apply DOE methodologies to improve production yield, efficiency, and consistency.
• Develop downstream purification processes, including filtration, tangential flow filtration (TFF), and chromatography.
• Perform viral vector characterization and quality control using molecular biology and analytical techniques.
• Analyze experimental data, maintain laboratory records and inventory, and prepare SOPs, technical reports, and presentations.
• Collaborate with cross-functional research teams to troubleshoot processes and improve experimental outcomes.

Skills

Mammalian cell culture

Transient transfection

Molecular biology techniques

DOE methodologies

Data interpretation

Documentation

Communication skills

Education

MS or PhD in Cell Biology / related field

Job description

Scientist II – Viral Vector Process Development

Location: Fully Onsite at South San Francisco, CA

Pay Rate: $36–$48/hour

Benefits: Weekly pay, medical, dental, vision, and disability coverage

Position Overview

We are seeking a motivated and collaborative Scientist II to support the development and optimization of lentiviral vector (LVV) and adeno-associated virus (AAV) production platforms. This role focuses on improving viral vector yield, production throughput, and quality to support research, screening, and therapeutic pipeline development.

Key Responsibilities

• Develop and optimize high-throughput LVV and AAV production workflows using automated liquid handling systems and parallel bioreactor platforms.
• Perform mammalian cell culture, transient transfection, viral vector production, and upstream process optimization.
• Apply Design of Experiments (DOE) methodologies to improve production yield, efficiency, and consistency.
• Develop downstream purification processes, including filtration, tangential flow filtration (TFF), and chromatography.
• Perform viral vector characterization and quality control using molecular biology and analytical techniques.
• Analyze experimental data, maintain laboratory records and inventory, and prepare SOPs, technical reports, and presentations.
• Collaborate with cross-functional research teams to troubleshoot processes and improve experimental outcomes.

Required Qualifications

• MS or PhD in Cell Biology, Molecular Biology, Virology, Biochemistry, Bioengineering, Genetics, or a related field.
• At least 3 years of laboratory research or industry experience.
• Hands-on experience with ex vivo CAR-T cell engineering using lentiviral vectors.
• Proficiency in mammalian cell culture, transient plasmid transfection, and molecular biology techniques, such as PCR, qPCR, ddPCR, dPCR, or Western blot.
• Strong analytical, data interpretation, documentation, and communication skills.

Preferred Qualifications

• Experience producing lentiviral or AAV vectors in adherent or suspension cell systems.
• Knowledge of upstream and downstream process development and viral vector purification.
• Experience with DOE, automated liquid handling systems, and high-throughput workflows.
• Familiarity with flow cytometry, electronic laboratory notebooks, and BSL-2 laboratory operations.