Scientist – Tissue Pathology & Biomarker Discovery

Amgen; South San Francisco (CA); On-site; USD 110,000 - 150,000; Full time

Job summary

Amgen is seeking a Scientist to join the Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) Department in South San Francisco, California. The Scientist will develop and apply tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy, and biomarker discovery.

Responsibilities include developing, optimizing, validating, and standardizing histopathology assays

Qualifications

• Doctorate degree in a relevant field or equivalent combination as listed.
• Master’s degree with 2+ years of relevant research/industry experience.
• Bachelor’s degree with 4 years of relevant research/industry experience.

Responsibilities

• Develop, optimize, validate, and standardize histopathology assays using FFPE samples, including single-plex and multiplex IHC and ISH.
• Use imaging modalities and digital pathology tools to generate, analyze, and interpret tissue-based data for target qualification, pharmacodynamic and efficacy assessments, and biomarker development.
• Collaborate with pathologists, research investigators, and translational teams to deliver high-quality data supporting mechanism-of-action studies and safety assessments across therapeutic areas.
• Maintain clear, complete documentation and communicate results through laboratory information systems, databases, and team presentations.

Skills

Pathology imaging

Digital pathology

Image analysis

Cross-functional collaboration

Communication skills

Education

Doctorate degree

Master’s degree + 2+ years

Bachelor’s degree + 4 years

Tools

HALO

Visiopharm

Ventana

Leica Bond

IntelliPATH

Job description

Amgen is seeking a Scientist to join the Pathology Laboratory within the Translational Safety & Risk Sciences (TSRS) Department in South San Francisco, California. The Scientist will develop and apply tissue-based assays, including multiplex assays and digital image analysis, to support target expression studies, preclinical model development, pharmacodynamics, efficacy, and biomarker discovery.

Responsibilities include developing, optimizing, validating, and standardizing histopathology assays