Scientist/Sr Scientist

BioSpace; Thousand Oaks (CA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Retirement plan

Medical/dental/vision coverage

Discretionary annual bonus

Stock-based incentives

Paid time off

Job summary

Amgen in Thousand Oaks, CA seeks a Scientist in mass spectrometry-based proteomics to drive high-throughput workflows for target identification and drug discovery. You will contribute to both pipeline advancement and platform innovation, developing automated sample prep, data acquisition, and analysis across diverse assays.

The role requires hands-on expertise with high-throughput MS systems (Orbitrap-based), strong troubleshooting, and collaborative problem-solving within a cross-functional

Qualifications

• Doctorate or equivalent in a relevant field.
• Masters with 2 years related experience.
• Bachelors with 4 years related experience.

Responsibilities

• Design and implement high-throughput proteomics workflows.
• Perform automated sample prep and LC-MS/MS analyses.
• Collaborate as SME with biology, chemistry, and therapeutic areas.
• Analyze proteomics data to inform mechanism of action and target engagement.
• Maintain and troubleshoot mass spectrometry systems and workflows.
• Present findings to cross-functional teams with clear documentation.

Skills

Mass spectrometry

Proteomics

High-throughput workflows

LC-MS/MS

Data analysis

Education

PhD/MD/PharmD with relevant experience

MS with 2 years related experience

BS with 4 years related experience

Tools

Orbitrap platforms

LCMS/MS platforms

Automation platforms

Job description

Join Amgens Mission of Serving Patients

At Amgen, if you feel like youre part of something bigger, its because you are. Our shared missionto serve patients living with serious illnessesdrives all that we do.

Since 1980, weve helped pioneer the world of biotech in our fight against the worlds toughest diseases. With our focus on four therapeutic areas Oncology, Inflammation, General Medicine, and Rare Disease we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, youll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, youll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

Scientist

What You Will Do

Lets do this. Letschange the world.

We are seeking a motivated Scientist in mass spectrometrybased proteomics to join our talented, collaborative team in Thousand Oaks, California. In this vital role, you will generate critical proteomic insights that support target identification, drug discovery, and the advancement of innovative screening technologies.

You will contribute across both pipeline advancement and screening-platform innovation by developing, implementing, and continuously improving cutting-edge, high-throughput proteomics workflows. This work includes automated sample preparation, mass spectrometry data acquisition and analysis across diverse assay formats, and the design and optimization of next-generation screening and analytical platforms.

The successful candidate will bring strong hands-on expertise in high-throughput mass spectrometry systems, along with a rigorous scientific mindset, sound troubleshooting skills, and an enthusiasm for collaborative drug discovery. Your work will enable innovative screening strategies, accelerate discovery programs, and strengthen proteomics support for the broader pipeline.

Key Responsibilities

• Design, develop, optimize, and implement high-throughput mass spectrometrybased proteomics workflows and screening platforms to accelerate drug discovery.
• Execute automated sample preparation and LCMS/MS analyses across a broad range of high-throughput proteomics assays.
• Collaborate closely with therapeutic area, biology and chemistry teams as a technical and scientific subject-matter expert, contributing to data-driven decision-making.
• Analyze and interpret proteomics data to generate insights into mechanism of action, target engagement, selectivity, and other key drug-discovery questions.
• Operate, maintain, troubleshoot, and continuously improve high-throughput mass spectrometry systems and associated analytical workflows.
• Present research findings at internal and external meetings, and clearly communicate experimental plans, results, and analyses to cross-functional teams.
• Maintain accurate, organized, and timely documentation of experiments, protocols, methods, and data analyses.

What We Expect Of You

The Senior Scientist weseekis a scientifically driven, collaborative, and innovative proteomics expert.

Basic Qualifications

• Doctorate degree (PhD, PharmD, or MD) with relevant experience;
• Masters degree and 2 years of directly related experience;
• Bachelors degree and 4 years of directly related experience.

Preferred Qualifications

• Doctorate degree in proteomics, chemoproteomics, biochemistry, chemistry, analytical science, or a related discipline.
• Hands-on experience developing, optimizing, and applying mass spectrometrybased proteomics assays and workflows.
• Experience operating and troubleshooting advanced LCMS/MS platforms, such as Orbitrap-based systems, and analyzing proteomics data.
• Experience with high-throughput sample preparation, miniaturization, and laboratory automation platforms.
• Demonstrated ability to develop, refine, or scale assays, analytical methods, or proteomics platforms.
• Quantitative and computational experience analyzing complex, high-dimensional proteomics datasets.
• Experience working in a biotechnology, pharmaceutical, or drug-discovery research environment is preferred.
• Ability to work effectively in a highly integrated, collaborative team environment; strong organizational, verbal, and written communication skills; and a demonstrated commitment to generating reliable, reproducible results.

What You Can Expect Of Us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, well support your journey every step of the way.

The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

In Addition To The Base Salary, Amgen Offers a Total Rewards Plan, Based On Eligibility, Comprising Of Health And Welfare Plans For Staff And Eligible Dependents, Financial Plans With Opportunities To Save Towards Retirement Or Other Goals, Work/life Balance, And Career Development Opportunities That May Include:

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan
• Stock-based long-term incentives
• Award-winning time-off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

Application Deadline

Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Internal Only Posting (or Pre-ID Candidate)

Amgen anticipates accepting applications until 1 week before the posting; however, we may continue accepting applications beyond this date if we do not receive a sufficient number of candidates.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.