Scientist/Senior Scientist, Protein Design

SystImmune; Redmond (WA); On-site; USD 150,000 - 250,000; Full time

Job summary

An established industry player is seeking a creative and motivated Protein Design Scientist to join its Computational Protein Design group. This role involves executing and enhancing the computational design pipeline, utilizing data-driven methods to support groundbreaking multi-specific biological programs. The ideal candidate will have extensive experience in protein design, molecular docking, and structural modeling, and will thrive in a collaborative environment. Join a stable and well-funded biotech company that offers a comprehensive benefits package and the opportunity to make significant contributions to cancer treatment advancements.

Benefits

100% paid employee premiums for medical/dental/vision

Short-term and long-term disability insurance

401(k) plan with company match

15 PTO days per year

Sick leave

11 paid holidays

Opportunities for learning and growth

Qualifications

• 8+ years of experience in protein binding or therapeutic antibodies.
• Proven expertise in computational methods for peptide and protein design.

Responsibilities

• Execute and improve computational design pipeline for macromolecular therapeutics.
• Collaborate within interdisciplinary teams to achieve company vision.

Skills

Computational Methods

Protein Design

Molecular Docking

Structural Modeling

Data Analysis

Collaboration

Education

PhD in Bioengineering

PhD in Biophysics

PhD in Biochemistry

PhD in Molecular Biology

Tools

AlphaFold

RoseTTAFold

RFdiffusion

ProteinMPNN

Gromacs

MOE

Schrödinger

Job description

Located in Redmond WA, SystImmune Inc. is a bio-pharmaceutical company focused on the treatment of cancer through developing novel therapeutic multi-specific antibodies, as well as antibody-drug conjugates (ADCs). Our objective is to create biologics that work through systematic intervention on the solid tumor micro-environment, to either directly attack the tumor and/or to activate the immune system to attack the tumor.

Summary: SystImmune Inc. is looking for a creative and motivated Protein Design Scientist or Senior Scientist to work in our Computational Protein Design group. As part of the early scientific team, this individual will be involved in executing and improving the Computational Protein Design pipeline, using data-driven approaches to augment SystImmune Inc’s first-in-class multi-specific biological programs.

The ideal candidate will have experience applying computational methods to design novel peptides and proteins, such as structural modeling and prediction, structure library generation, molecular docking, and multiparameter molecular property optimization. A successful candidate will be an excellent collaborator working closely with our Antibody Discovery, Protein Engineering, and Immuno-oncology teams.

Essential Duties and Responsibilities:

• Execute and improve a computational design pipeline for predicting the properties of peptides, natural ligands, de novo proteins, and antibody-based elements via data-driven approach.
• Drive assay validation, tech transfer, and development initiatives to maintain industry standards; contribute within the computational protein design group to operate yeast display-based protein discovery platforms.
• Design new macromolecular therapeutics using structural and sequence analysis, and employ these in silico predictions to iteratively guide the lead development process.
• Analyze, interpret, document and present data to the scientific and leadership team.
• Work within a collaborative, interdisciplinary team to actively contribute to executing the vision of the company.

Qualifications:

• PhD (or equivalent) in bioengineering, biophysics, biochemistry, molecular biology, cell biology, or a related field.
• 8+ years of experience using yeast libraries to generate protein binding or therapeutic antibodies required.
• Experience applying computational methods to solve problems related to peptide and protein design, modeling, and sequence/structure-function prediction, experienced with relevant macromolecular modeling software (i.e. AlphaFold, RoseTTAFold, RFdiffusion, ProteinMPNN, Gromacs, MOE, Schrödinger).
• Expertise in screening and ranking of antibodies (ELISA, multi-parametric flow cytometry, BLI/OCTET).
• Proven contribution to therapeutic antibody development and selection is desirable. Design and validate novel and biologically relevant antibodies is highly desirable.

The hiring pay range for this position is $150,000 - $250,000 per year based on skills, education, and experience relevant to the role.

SystImmune is a stable, well-funded biotech company with a bright future. We offer an opportunity for you to learn and grow while making significant contributions to the company’s success. SystImmune offers a comprehensive benefits package including: 100% paid employee premiums for medical/dental/vision, also STD, LTD, a 401(k) plan with a 50% company match of up to 3% and a vesting schedule of only 5 years, 15 PTO days per year, sick leave, plus 11 paid holidays and MORE.

SystImmune is an Equal Opportunity Employer.