Scientist / Senior Scientist, Analytical Development

Sci.bio Recruiting; Boston (MA); On-site; USD 120,000 - 180,000; Full time

Job summary

Sci.bio Recruiting seeks a Scientist/Senior Scientist, Analytical Development to advance peptide-based programs. The role emphasizes hands-on development, optimization, and implementation of analytical methods for peptides, conjugates, and related drug substances.

Expertise with HPLC/UPLC, peptide chemistry, and data interpretation is essential. Collaborate with chemistry, radiochemistry, process development, CMC, and other teams to guide program decisions, troubleshoot issues, and generate

Qualifications

• PhD in Analytical Chemistry or related discipline with ~3+ years industry experience or MS/BS with substantial relevant experience.
• Experience in analytical development and characterization of peptides or peptide-based therapeutics.
• Hands-on experience with HPLC/UPLC method development and troubleshooting.

Responsibilities

• Develop, optimize, qualify, and troubleshoot analytical methods for peptides, peptide conjugates, intermediates, precursors, and related drug substances.
• Serve as a subject‑matter expert for HPLC and UPLC, focusing on reversed‑phase methods for purity, identity, and related‑substance analysis.
• Characterize peptide products for purity, identity, degradation products, impurities, stability, and other quality attributes.
• Use LC‑MS/MS, mass spectrometry, and other physicochemical characterization methods.
• Support analytical characterization of peptide synthesis, purification, and conjugation.
• Develop stability‑indicating methods; support forced-degradation and stability studies.
• Interpret analytical data with chemistry, radiochemistry, process development, CMC, and other teams.
• Investigate unexpected results, impurity profiles, method-performance issues, and product-quality questions.
• Author methods, protocols, reports, specifications, and development documentation.
• Support method transfer and oversight of CRO/CDMO partners.
• Contribute to analytical strategies from discovery to GMP readiness.
• Maintain data integrity and lab safety.

Skills

HPLC/UPLC

Peptide Chemistry

Analytical Method Development

LC-MS/MS

Data Interpretation

Cross-functional Collaboration

Communication Skills

Education

PhD in Analytical Chemistry or related field

MS/BS with significant industry experience

Tools

Waters Empower

HPLC/UPLC Instrumentation

Mass Spectrometry

Job description

We are seeking a highly skilled Scientist/Senior Scientist, Analytical Development to support the development of peptide-based programs. This individual will play a key hands‑on role in developing, optimizing, and implementing analytical methods used to characterize peptides, peptide conjugates, intermediates, and drug substances throughout development.

The ideal candidate brings deep expertise in HPLC/UPLC-based analytical development, strong knowledge of peptide chemistry and characterization, and the ability to troubleshoot complex analytical problems in a fast-moving research and development environment.

Responsibilities

• Develop, optimize, qualify, and troubleshoot analytical methods for peptides, peptide conjugates, intermediates, precursors, and related drug substances.
• Serve as a subject‑matter expert for HPLC and UPLC, with particular emphasis on reversed‑phase chromatographic methods for purity, identity, and related‑substance analysis.
• Characterize peptide products with respect to purity, identity, degradation products, impurities, stability, and other critical quality attributes.
• Use complementary analytical techniques including LC‑MS/MS, mass spectrometry, and other appropriate physicochemical characterization methods.
• Support analytical characterization of peptide synthesis, purification, and conjugation,
• Develop stability‑indicating methods and support formulation, forced‑degradation, and stability studies.
• Partner closely with chemistry, radiochemistry, process development, CMC, and other technical functions to interpret analytical data and guide program decisions.
• Investigate unexpected analytical results, impurity profiles, method‑performance issues, and product‑quality questions.
• Author analytical methods, protocols, technical reports, specifications, and development documentation.
• Support method transfer and technical oversight of external CRO/CDMO partners.
• Contribute to analytical strategies appropriate for progression from discovery and preclinical development toward IND‑enabling and GMP activities.
• Maintain high standards for data integrity, documentation, and laboratory safety.

Required Skills

• PhD in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical Sciences, or a related discipline, with approximately 3+ years of relevant industry experience; or MS/BS with substantial directly relevant industry experience.
• Demonstrated expertise in the analytical development and characterization of peptides or peptide‑based therapeutics.
• Extensive hands‑on experience with HPLC and UPLC method development and troubleshooting.
• Experience with Waters HPLC/UPLC instrumentation and Empower software strongly preferred.
• Strong understanding of chromatographic method development, including gradients, columns, mobile‑phase selection, selectivity, resolution, and impurity separation.
• Experience with LC‑MS or other mass‑spectrometry‑based characterization of peptides.
• Understanding of peptide degradation pathways, related substances, chemical stability, and impurity profiling.
• Ability to independently design experiments, interpret complex datasets, troubleshoot methods, and communicate conclusions to multidisciplinary project teams.
• Strong written and verbal communication skills and the ability to operate effectively in a highly collaborative, fast‑paced environment.