Scientist, Quantitative Bioanalytics - Analytical and Biological Mass Spectrometry (ABMS)

Regeneron Pharmaceuticals, Inc.; Village of Tarrytown (NY); On-site; USD 110,000 - 165,000; Full time

Job summary

Regeneron Pharmaceuticals, Inc. in Tarrytown, NY seeks a Scientist to join the Quantitative Bioanalytics (QBA) team in ABMS.

You will develop and qualify LC-MS-based bioanalytical assays for biotherapeutics and biomarkers, supporting diverse R&D programs with cross-functional partners and advancing bioanalytical methods. This role emphasizes independent project ownership, data integrity, and effective communication in a fast-paced, science-driven environment, with opportunities to contribute to

Qualifications

• 6+ years (MS) or 8+ years (BS) of LC-MS bioanalytical experience.
• Hands-on LC-MS with triple quadrupole, Q-TOF and Orbitrap.
• GxP environment experience and regulatory documentation a plus.
• Strong understanding of method qualification and validation for large-molecule bioanalysis.

Responsibilities

• Perform LC-MS-based assay development, qualification, and validation for biotherapeutics and biomarkers in biological matrices.
• Provide bioanalytical support for research, preclinical and clinical studies by quantifying therapeutics or biomarkers.
• Operate LC-MS platforms (triple quadrupole, Q-TOF, Orbitrap) with automated/sample prep.
• Troubleshoot methods and ensure data quality and scientific integrity.
• Maintain ELNs and document results; communicate findings in reports and regulatory documents.
• Develop and troubleshoot analytical methods; explore new technologies.
• Collaborate across teams to coordinate samples, timelines and deliverables.
• Think independently on defined projects while collaborating in a team.
• Communicate clearly with both verbal and written skills.
• Be results-driven, adaptable and scientifically curious in a fast-paced R&D environment.

Skills

Mass spectrometry

Bioanalysis

Team collaboration

Education

BS or MS in Chemistry, Biochemistry, Analytical Chemistry

Tools

LC-MS platforms

Q-TOF

Orbitrap

Triple quadrupole

Job description

Build our future together:

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a highly motivated and collaborative Scientist to join the Quantitative Bioanalytics (QBA) team within the Analytical and Biological Mass Spectrometry (ABMS) Group. In this exciting role, you will work in a pioneering, state-of-the-art mass spectrometry laboratory to develop, qualify, and apply LC-MS-based bioanalytical assays and other analytical methods to support R&D programs. You will have opportunities to contribute to innovative mass spectrometry technologies applied to bioanalysis and biologics characterization across Regeneron's diverse and evolving therapeutic pipeline, while collaborating closely with cross-functional teams to understand bioanalytical needs, coordinate samples and study activities, and align priorities and timelines.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & where:

• Shift Requirements: Full-time
• Location: On-site in Tarrytown, NY

Discover your role:

• Perform LC-MS-based assay development, qualification, and validation for biotherapeutics and biomarkers in biological matrices to support Regeneron's R&D pipelines
• Perform bioanalysis and provide bioanalytical support for research, preclinical, clinical, and biodistribution studies by quantifying therapeutics or biomarkers in biological study samples, with increasing independence and project ownership
• Apply state-of-the-art LC-MS (e.g., triple quadrupole, Q-TOF, and Orbitrap) coupled with manual or automated sample preparation (e.g., liquid handlers and other automation robots) to investigate biotherapeutics, including antibodies, antibody-drug conjugates (ADCs), antibody-oligonucleotide conjugates (AOCs), antibody-tethered ligands (ATLs), adeno-associated viruses (AAVs), peptides, and other novel modalities
• Troubleshoot and optimize methods, and ensure data quality and scientific integrity of bioanalytical and biologics characterization results, to support data-driven decisions
• Maintain accurate and reliable records, including electronic lab notebooks (ELNs) and other pertinent documentation; analyze and interpret results; and effectively communicate findings at team and cross-functional meetings, and in technical reports, regulatory documents, conferences, and peer-reviewed publications
• Work in a laboratory-based role with strong support for skill and career development, while taking increasing ownership of projects and priorities
• Develop and troubleshoot analytical methods, solve scientific and technical problems, and explore new technologies and approaches to address bioanalytical challenges
• Demonstrate excellent attention to detail, good record keeping, and organizational skills
• Work independently and collaboratively across teams, build productive working relationships, and coordinate samples, activities, priorities, timelines, and deliverables across multiple programs
• Think and act independently on well-defined projects, while working collaboratively in a team environment and adapting to changing priorities
• Communicate clearly and effectively, with excellent verbal and written communication skills
• Be results-driven, adaptable, and scientifically curious, with the ability to thrive in an innovative, fast-paced R&D environment

This role requires:

• BS or MS in Chemistry, Biochemistry, Analytical Chemistry, Pharmaceutical Sciences, or a related field
• 6+ years (MS) or 8+ years (BS) of industrial or academic experience with LC-MS based bioanalytical assays for biomarkers, protein therapeutics, antibodies, AAVs, or other therapeutic modalities
• Hands-on experience with LC-MS and advanced mass spectrometry platforms, such as triple quadrupole, Q-TOF, and Orbitrap, with a strong understanding of mass spectrometry techniques and their applications to large-molecule analysis
• Experience with GxP laboratory environment, documentation, and regulatory compliance in the biotech or biopharmaceutical industry is a plus
• Deep understanding of analytical method qualification and validation is highly desired; knowledge of ELISA and other ligand-binding assays is a plus

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected un