Scientist, Pharmacokinetics

Merck; South San Francisco (CA); On-site; USD 108,000 - 170,000; Full time

Job summary

Merck in South San Francisco is seeking a highly motivated scientist for the DMPK group to support preclinical development of diverse therapeutics. The role emphasizes in vitro/ex vivo ADME studies, integration of data, and collaboration across multiple therapeutic areas to drive pipeline decisions.

The candidate should have hands-on mammalian cell culture, LC-MS/MS bioanalysis, and experience with protein characterization or flow-based assays as pluses.

Qualifications

• Demonstrated experience with mammalian cell culture and performing cell-based assays.
• Hands-on experience operating LC-MS/MS instrumentation, preferably SCIEX QQQ platforms, for quantitative bioanalysis.
• Understanding of basic safety protocols, laboratory practices, and quality expectations in a research environment.

Responsibilities

• Plan and conduct in vitro/ex vivo studies to evaluate ADME properties of biologics and other modalities.
• Interpret data, integrate findings, and clearly present results to inform pipeline decisions.
• Contribute to scientific initiatives advancing ADME and discovery bioanalytical science.

Skills

Bioanalysis

Cell-Based Assays

Mammalian Cell Culture

Mass Spectrometry

Education

Bachelor's degree (with 3 years) or Master's in analytical science/biochemistry/biology/pharmaceutical sciences

Tools

LC-MS/MS

SCIEX QQQ

Job description

The Pharmacokinetics, Dynamics, Metabolism, And Bioanalytics (PDMB) organization at our company's Research Laboratories is seeking a highly motivated and collaborative scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) group in South San Francisco (SSF). The Scientist will provide laboratory support for the multi-disciplinary drug discovery effort in SSF, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology.

The scientist will work within a highly collaborative team and contribute to characterization of novel drug candidates in a range of therapeutic areas, including immunology, oncology, cardiovascular and metabolic disease, and ophthalmology. The scientist will be responsible for planning and conducting in vitro/ex vivo studies to evaluate the absorption, distribution, metabolism and excretion (ADME) properties of biologics, conjugates and other modalities. The ideal candidate will work with the team and interpret data, integrate, and clearly present results to help the team inform pipeline decisions. The candidate will also contribute to scientific initiatives for further advancing our knowledge of ADME and discovery bioanalytical science.

The successful candidate should have hands-on experience with in vitro and ex vivo cellular assays to characterize biologics and conjugates, as well as LC-MS/MS-based bioanalytical methodologies. Experience handling biological matrices and developing quantitative assays for drug and biomarker measurements is highly desirable. The scientist must be highly motivated, able to work collaboratively in a fast-paced environment, and possess excellent scientific, interpersonal, and communication skills.

Qualifications

Education

• Bachelor's (with 3 years) or Master's in analytical science, biochemistry, biology, pharmaceutical sciences, chemistry, pharmacology, biochemical engineering, biophysics, or a related discipline and relevant experience

Required Experience And Skills

• Demonstrated experience with mammalian cell culture and performing cell-based assays
• Hands-on experience operating LC-MS/MS instrumentation, preferably SCIEX QQQ platforms, for quantitative bioanalysis
• Understanding of basic safety protocols, laboratory practices, and quality expectations in a research environment

Preferred Experience And Skills

• Previous experience in a research environment or/and in drug discovery and development
• Demonstrated experience with protein characterization using biochemical or biophysical techniques
• Previous experience with flow cytometry-based assays and analysis
• Previous experience developing or performing automated assays
• General knowledge of PK, ADME and/or drug discovery concepts is a plus not a must
• Demonstrated creativity and innovation via a publication/presentation record
• Proficient in using data analysis software, such as graphpad, excel, etc.
• Experience in using electronic notebooks is desirable

Required Skills

Bioanalysis, Cell-Based Assays, Cell Culture Techniques, Laboratory Techniques, Mammalian Cell Culture, Mammalian Cell Lines, Mass Spectrometry (MS)

Requirements

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:

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We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.

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The salary range for this role is

$108,000.00 - $170,100.00

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

San Francisco Residents Only:

We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:

We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Search Firm Representatives Please Read Carefully

Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.

Employee Status

Regular

Relocation

Domestic

VISA Sponsorship

No

Travel Requirements

No Travel Required

Flexible Work Arrangements

Not Applicable

Shift

1st - Day

Valid Driving License

No

Hazardous Material(s)

N/A

Job Posting End Date

• A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Requisition ID

R415362