Scientist, Bioanalytical

MSD Malaysia; South San Francisco (CA); On-site; USD 89,000 - 140,000; Full time

Benefits offered by this job

Medical, dental, vision insurance

401(k) retirement benefits

Paid holidays and vacation

Job summary

Merck in South San Francisco seeks a highly motivated scientist to join the DMPK group supporting preclinical development across modalities. You will design and execute in vitro/ex vivo DMPK studies, interpret complex data, and clearly present results to guide decisions. Strong collaboration and communication are essential.

Required skills include cell culture, biologics bioanalysis, ligand binding assays, and proficiency with GraphPad and Excel; PK/ADME knowledge and automated assays are a plus.

Qualifications

• Mammalian cell culture experience and cell-based assays.
• Experience in biologics bioanalytical work such as ligand binding assays.
• Background in PK/ADME concepts is a plus.

Responsibilities

• Plan and conduct in vitro/ex vivo DMPK studies for biologics and other modalities.
• Interpret data and present results to inform pipeline decisions.
• Collaborate with cross-functional teams and contribute to scientific initiatives.

Skills

Mammalian cell culture

Cell-based assays

Biologics bioanalytical

Ligand binding assays

FACS

PK/ADME knowledge

Publication record

GraphPad

Excel

Electronic notebooks

Education

Bachelor's with 3+ years or Master's in analytical sciences/related field

Tools

GraphPad Prism

Excel

Electronic notebooks

Job description

Job Description

The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) organization at our company's Research Laboratories is seeking a highly motivated and collaborative scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) group in South San Francisco (SSF). The Scientist will provide laboratory support for the multi-disciplinary drug discovery effort in SSF, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology. The scientist will work within teams of highly collaborative scientists to contribute to characterization of novel drug candidates in a range of therapeutic areas. The scientist will be responsible for planning and conducting in vitro/ex vivo studies to the DMPK properties of biologics, conjugates and other modalities. The ideal candidate will work with the team and interpret data, integrate, and clearly present results to help the team inform pipeline decisions. The candidate will also contribute to scientific initiatives for further understanding of ADME and discovery bioanalytical science. The successful candidate should have knowledge and hands‑on experience with biologics bioanalytical, cell‑based assays and handling biomatrices. The scientist must be highly motivated, able to work collaboratively in a fast‑paced environment and have excellent scientific, interpersonal, and communication skills.

Qualifications

Education: Bachelor's with (3+ years) or Master's in analytical science, biology, biochemistry, pharmaceutical sciences, chemistry, pharmacology, biochemical engineering, biophysics or related discipline and relevant experience.

Required Experience and Skills

• Demonstrated experience with mammalian cell culture and performing cell-based assays.
• Demonstrated experience in biologics bioanalytical experimentation, such as ligand binding assays, FACS, etc.

Preferred Experience and Skills

• Previous experience in a research environment or/and in drug discovery and development.
• Demonstrated experience with protein characterization using biochemical or biophysical techniques.
• Previous experience developing or performing assays with automated system.
• General knowledge of PK, ADME and/or drug discovery concepts is a plus not a must.
• Demonstrated creativity and innovation via a publication/presentation record.
• Proficient in using data analysis software, such as Graphpad, Excel, etc.
• Experience in using electronic notebooks is desirable.

Required Skills

• Bioanalysis
• Bioanalytical Methods
• Bioanalytical Techniques
• Cell-Based Assays
• Cell Cultures
• Ligand Binding
• Ligand Binding Assay
• Mammalian Cell Culture
• Pharmacokinetics

US and Puerto Rico Residents Only: Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here if you need an accommodation during the application or hiring process.

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.

As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights EEOC GINA Supplement

We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts

Salary and Compensation

The salary range for this role is $89,000.00 - $140,100.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Employee Status: Regular Relocation: No relocation VISA Sponsorship: No Travel Requirements: No Travel Required Flexible Work Arrangements: Not Applicable Shift: Not Indicated Valid Driving License: No Hazardous Material(s): N/A

Job Posting End Date: 09/18/2026 *A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.

Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where we have codified our legacy for over a century. Our success is backed by ethical integrity, forward momentum, and an inspiring mission to achieve new milestones in global healthcare.