Scientist, Bioanalytical

MSD; South San Francisco (CA); On-site; USD 89,000 - 140,000; Full time

Benefits offered by this job

Medical insurance

Dental and vision

401(k) retirement

Paid time off

Job summary

Merck's Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) group in South San Francisco seeks a collaborative Scientist to support DMPK for preclinical drug development across modalities. You will plan and conduct in vitro/ex vivo studies to characterize DMPK properties of biologics and other modalities.

The role involves teamwork, data interpretation, and presenting results to guide pipeline decisions.

Qualifications

• Bachelor's with (3+ years) or Master's in analytical science, biology, biochemistry, pharmaceutical sciences, chemistry, pharmacology, biochemical engineering, biophysics or related discipline and relevant experience.
• Demonstrated experience with mammalian cell culture and performing cell-based assays.
• Demonstrated experience in biologics bioanalytical experimentation, such as ligand binding assays, FACS, etc.
• Preference for experience in research/drug discovery, protein characterization, and automated systems; PK/ADME knowledge is a plus.

Responsibilities

• Plan and conduct in vitro/ex vivo DMPK studies on biologics and other modalities.
• Collaborate with cross-functional teams and clearly present results to influence pipeline decisions.
• Interpret data, integrate findings, and contribute to ADME and discovery bioanalytical initiatives.
• Support preclinical development and contribute to scientific initiatives within DMPK.

Skills

Bioanalysis

Bioanalytical Methods

Bioanalytical Techniques

Cell-Based Assays

Cell Cultures

Ligand Binding

Ligand Binding Assay

Mammalian Cell Culture

Pharmacokinetics

Education

Analytical science degree

Tools

GraphPad

Excel

Job description

The Pharmacokinetics, Dynamics, Metabolism, and Bioanalytics (PDMB) organization at our company's Research Laboratories is seeking a highly motivated and collaborative scientist to join the Drug Metabolism and Pharmacokinetics (DMPK) group in South San Francisco (SSF). The Scientist will provide laboratory support for the multi-disciplinary drug discovery effort in SSF, with a focus on supporting preclinical development of therapeutics of various modalities through integrated understanding of drug disposition and pharmacology.

The scientist will work within teams of highly collaborative scientists to contribute to characterization of novel drug candidates in a range of therapeutic areas. The scientist will be responsible for planning and conducting in vitro/ex vivo studies to the DMPK properties of biologics, conjugates and other modalities. The ideal candidate will work with the team and interpret data, integrate, and clearly present results to help the team inform pipeline decisions. The candidate will also contribute to scientific initiatives for further understanding of ADME and discovery bioanalytical science.

The successful candidate should have knowledge and hands‑on experience with biologics bioanalytical, cell‑based assays and handling biomatrices. The scientist must be highly motivated, able to work collaboratively in a fast‑paced environment and have excellent scientific, interpersonal, and communication skills.

QUALIFICATIONS

Education

• Bachelor's with (3+ years) or Master's in analytical science, biology, biochemistry, pharmaceutical sciences, chemistry, pharmacology, biochemical engineering, biophysics or related discipline and relevant experience.

• Demonstrated experience with mammalian cell culture and performing cell‑based assays.
• Demonstrated experience in biologics bioanalytical experimentation, such as ligand binding assays, FACS, etc.

Preferred Experience and Skills

• Previous experience in a research environment or/and in drug discovery and development.
• Demonstrated experience with protein characterization using biochemical or biophysical techniques.
• Previous experience developing or performing assays with automated system.
• General knowledge of PK, ADME and/or drug discovery concepts is a plus not a must.
• Demonstrated creativity and innovation via a publication/presentation record.
• Proficient in using data analysis software, such as Graphpad, Excel, etc.
• Experience in using electronic notebooks is desirable.

Required Skills: Bioanalysis, Bioanalytical Methods, Bioanalytical Techniques, Cell‑Based Assays, Cell Cultures, Ligand Binding, Ligand Binding Assay, Mammalian Cell Culture, Pharmacokinetics

As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics.

As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities.

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The salary range for this role is $89,000.00 - $140,100.00. This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs.

The successful candidate will be eligible for annual bonus and long‑term incentive, if applicable.

We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits.

San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance

Employee Status: Regular

Relocation: No relocation

VISA Sponsorship: No

Travel Requirements: No Travel Required

Flexible Work Arrangements: Not Applicable

Shift: Not Indicated

Valid Driving License: No

Hazardous Material(s): N/A

Job Posting End Date: 09/18/2026*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date.