Scientist, Oncology Research

Scorpion Therapeutics; California (MO); On-site; USD 90,000 - 130,000; Full time

Job summary

Gilead is seeking a Collaborative Scientist to join the Tumor Intrinsic Biology group and lead early discovery research on cancer cell regulatory mechanisms. You will design and perform experiments that illuminate transcriptional regulation and oncogenic signaling in collaboration with multiple disciplines.

The role emphasizes mechanistic understanding and cross-team communication to accelerate target identification and validation in an active cancer biology program.

Qualifications

• Bachelor's degree with 5+ years, Master's with 3+ years, or Ph.D. with no minimum experience.
• Strong expertise in protein and nucleic acid biochemistry, biophysics, molecular biology.
• Experience with macromolecular complex reconstitution, interaction assays (e.g., SPR, BLI, EMSA).
• Knowledge of transcriptional regulation, RNA biology, chromatin, and cancer signaling.

Responsibilities

• Design and conduct experiments on protein-nucleic acid complexes involved in transcription, lineage control, and oncogenic signaling.
• Develop biochemical, biophysical, and cellular approaches to study regulatory mechanisms.
• Generate mechanistic insights to support target identification and validation.
• Collaborate across oncology biology, chemistry, structural biology, translational medicine, and computational sciences.
• Communicate findings effectively.

Skills

Protein biochemistry

Nucleic acid biochemistry

Biophysics

Molecular biology

Macromolecular complexes

SPR/BLI/EMSA

Transcriptional regulation

RNA biology

Chromatin

Cancer signaling

Education

Bachelor's degree

Master's degree

PhD

Job description

Role:

Collaborative Scientist within Gilead's Tumor Intrinsic Biology group, focusing on early discovery research of cancer cell regulatory mechanisms.

Responsibilities:

design and conduct experiments on protein-nucleic acid complexes involved in transcription, lineage control, and oncogenic signaling; develop biochemical, biophysical, and cellular approaches; generate mechanistic insights to support target identification and validation; collaborate across oncology biology, chemistry, structural biology, translational medicine, and computational sciences; communicate findings effectively.

Requirements:

Bachelor's degree with 5+ years, Master's with 3+ years, or Ph.D. with no minimum experience; strong expertise in protein and nucleic acid biochemistry, biophysics, molecular biology; experience with macromolecular complex reconstitution, interaction assays (e.g., SPR, BLI, EMSA); knowledge of transcriptional regulation, RNA biology, chromatin, and cancer signaling.

Preferred:

extensive experience in protein-nucleic acid biochemistry, reconstitution from human cells, and working with transcriptional programs relevant to cancer.

High Value:

focus on transcriptional regulation, lineage control, and oncogenic pathways; early discovery stage; multidisciplinary collaboration; emphasis on molecular mechanisms underlying tumor biology.

Work Setup:

not specified; position likely based in research environment with collaborative, dynamic projects.