Scientist, Oncology & Cell Biology (CRISPR/Cell Lines)

BeOne Medicines; San Carlos (CA); On-site; USD 137,000 - 171,000; Full time

Benefits offered by this job

Annual bonus

Equity / stock options

Comprehensive benefits package

Job summary

BeOne Institute in San Carlos, CA is seeking a Scientist to conceptualize, enable, and advance cutting-edge research in oncology and immunology. You will design and execute experiments to identify novel targets and mechanisms, and develop engineered cell models to translate insights into actionable therapies.

The ideal candidate will hold a PhD, bring strong cell biology expertise (CRISPR, RNAi, genome-wide profiling), and thrive in a collaborative, fast-paced environment while maintaining

Qualifications

• Ph.D. or equivalent advanced degree in biology, biochemistry, chemistry, bioengineering, or a related scientific field, with relevant research experience
• Strong hands-on expertise in mammalian cell biology, including CRISPR-based knockout/knock-in, RNAi-mediated knockdown, or related methods
• Demonstrated ability to independently design, execute, troubleshoot, and interpret experiments to investigate biological mechanisms and test scientific hypotheses
• Experience generating and characterizing engineered cell lines for mechanistic studies
• Experience with transcriptomics (e.g., RNA-seq), chromatin profiling (e.g., ATAC-seq, CUT&RUN/CUT&Tag), high-content imaging, or other genomic and/or phenotypic profiling approaches
• Strong quantitative and analytical skills, with the ability to analyze, interpret, and communicate experimental data and draw biologically meaningful conclusions
• Ability to learn and apply new experimental approaches and technologies as research priorities evolve; demonstrated versatility across biological questions and experimental systems
• Strong scientific judgment and problem-solving skills, with a track record of identifying experimental strategies to address challenging or ambiguous biological questions
• Ability to operate effectively in a highly collaborative, fast-paced, and interdisciplinary research environment, and to integrate multi-disciplinary approaches to solve complex biological problems
• Excellent communication and presentation skills, with the ability to clearly articulate complex scientific concepts to both technical and non-technical audiences
• Be able to work on-site in San Carlos, CA

Responsibilities

• Lead or co-lead exploratory efforts on novel targets and new approaches to high-impact targets within oncology, immunology, or other disease areas
• Design, enable, execute, and interpret cellular experiments to probe mechanisms and test target hypotheses
• Generate and characterize engineered cell models, including cell lines incorporating genetic perturbations such as knockouts, knockdowns, or other targeted modifications
• Develop and apply appropriate experimental approaches, including emerging technologies and profiling methods, to address complex and evolving biological questions
• Stay up-to-date on project-relevant literature and state-of-the-art techniques; be adaptable and independently follow the science
• Communicate progress through regular updates while proactively identifying challenges and proposing solutions
• Collaborate with cross-disciplinary or cross-functional teams and drive innovation within and beyond the Institute
• Contribute to management and operational activities to support strategic objectives of the BeOne Institute at the San Carlos site
• Maintain impeccable ELN records

Skills

CRISPR knockout/knock-in

RNAi knockdown

Cell culture

Data analysis

Education

Ph.D. or equivalent advanced degree in biology/biochemistry/chemistry/bioengineering

Tools

RNA-Seq

ATAC-Seq

CUT&RUN

CUT&Tag

High-content imaging

Job description

BeOne Institute in San Carlos, CA is seeking a Scientist to conceptualize, enable, and advance cutting-edge research in oncology and immunology. You will design and execute experiments to identify novel targets and mechanisms, and develop engineered cell models to translate insights into actionable therapies.

The ideal candidate will hold a PhD, bring strong cell biology expertise (CRISPR, RNAi, genome-wide profiling), and thrive in a collaborative, fast-paced environment while maintaining