Scientist, NGS - Viral Delivery Technologies

BioSpace; Village of Tarrytown (NY); On-site; USD 94,000 - 153,000; Full time

Job summary

Regeneron is seeking a Scientist to join the Viral Delivery Technologies group in Tarrytown, NY. You will design, validate, and optimize antibody-retargeted AAV vectors, performing in vitro and in vivo studies and coordinating with analytical teams across Research & Discovery to advance a screening platform.

The role emphasizes molecular biology, NGS, and protein analysis with a fast-paced, collaborative team. Onsite work required in a science-driven environment that supports career growth.

Qualifications

• Strong NGS library preparation, optimization, troubleshooting and QC.
• Molecular biology experience including DNA isolation, PCR, plasmid cloning.
• Mammalian cell culture and handling, and protein/virus purification.
• Excellent presentation and communication skills.
• Familiarity with antibody properties, viral vector production, and related software.

Responsibilities

• Design, execute, analyze and troubleshoot in vitro and in vivo experiments to validate antibody-retargeted viral vectors.
• Develop and optimize NGS library prep workflows for screening and characterization.
• Design AAV genomes and perform recombinant AAV production for vector optimization.
• Collaborate with bioinformatics to analyze large NGS datasets.
• Prepare updates and presentations for team and departmental forums.
• Balance multiple projects with high attention to detail in a fast-paced environment.

Skills

NGS proficiency

Mammalian cell culture

Molecular biology

Data analysis

Communication skills

Education

Bachelor's degree + 8+ years OR MS + 6+ years in biology

Tools

Benchling

GraphPad Prism

MacVector

Microsoft Office

Job description

Build Our Future Together

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Scientist to join our Viral Delivery Technologies group, supporting the development of a new screening platform for antibody-retargeted adeno-associated virus (AAV) vectors. In this role, you will contribute to the design, characterization, and in vitro/in vivo validation of novel AAV vectors, expanding the company's gene therapy delivery portfolio while collaborating with cross-functional team members, analytical groups, and core facilities across Research and Discovery.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & Where

Location: Tarrytown, NY

Work model/flexibility: Onsite

Discover Your Role

• Design, execute, analyze, and troubleshoot in vitro and in vivo experiments to characterize and validate antibody-retargeted viral vector designs and screening protocols
• Apply molecular biology and protein analysis techniques, including cloning, SDS-PAGE, Western blotting, DNA/RNA extraction, PCR, RT-PCR, digital droplet PCR, and qPCR
• Design AAV genomes and execute recombinant AAV (rAAV) production protocols to inform novel vector optimizations
• Develop, optimize, and troubleshoot next-generation sequencing (NGS) library preparation workflows for screening and characterization applications
• Partner with the bioinformatics team to analyze large NGS datasets
• Prepare regular updates and presentations for team and departmental forums
• Thrive in an innovative, highly collaborative, fast-paced environment
• Work rigorously with close attention to detail while balancing multiple projects

This Role Requires

• B.A./B.S. with 8+ years of relevant industry or academic experience, or M.S. in cell biology, molecular biology, biochemistry, bioengineering, antibody science, or a related field with 6+ years of relevant experience
• Proficiency in next-generation sequencing (NGS), including library preparation, optimization, troubleshooting, and quality assessment
• Strong molecular biology experience, including DNA isolation, PCR-based methods, and plasmid cloning
• Experience in mammalian cell culture and manipulation, and in the purification of viruses and/or proteins
• Excellent presentation and communication skills
• Preferred: familiarity with key antibody properties, viral vector production, and relevant research software (e.g., Microsoft Office, GraphPad Prism, Benchling, MacVector)

Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits.

Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• annual bonuses or other incentive plans
• equity awards
• pension or retirement benefits
• 401(k) company match
• health and wellness programs
• fitness centers
• insurance benefits (e.g. medical, dental, vision, life and disability)
• paid time off
• family support benefits

For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed onsite.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Salary Range (annually)

$93,900.00 - $153,300.00