Scientist, NGS - Viral Delivery Technologies

Regeneron Pharmaceuticals; Tarrytown (GA); On-site; USD 94,000 - 153,000; Full time

Job summary

Regeneron Pharmaceuticals in Tarrytown, NY, seeks a Scientist to join the Viral Delivery Technologies group to develop an antibody-retargeted AAV screening platform. You will design, validate, and optimize vectors, and work with cross-functional teams to advance gene therapy delivery solutions.

The role emphasizes in vitro/in vivo experimentation, molecular biology techniques, and advanced sequencing workflows, with onsite work and regular project updates across research teams.

Qualifications

• 8+ years relevant industry or academic experience with BA/BS, or 6+ years with MS
• NGS library prep, optimization, troubleshooting, and QC experience
• Strong molecular biology experience including DNA isolation, PCR, and cloning
• Mammalian cell culture and manipulation; purification of viruses/proteins
• Excellent presentation and communication skills
• Familiar with software tools (Office, GraphPad Prism, Benchling, MacVector)

Responsibilities

• Design, execute, analyze, and troubleshoot in vitro and in vivo experiments to characterize antibody-retargeted viral vector designs and screening protocols
• Apply molecular biology techniques including cloning, SDS-PAGE, Western blotting, DNA/RNA extraction, PCR, RT-PCR, ddPCR, and qPCR
• Design AAV genomes and perform recombinant AAV production to inform vector optimizations
• Develop and optimize NGS library preparation workflows for screening and characterization
• Collaborate with bioinformatics to analyze large NGS datasets
• Prepare regular updates and presentations for team and department forums
• thrive in a fast-paced, collaborative environment with attention to detail while juggling multiple projects

Skills

NGS proficiency

Molecular biology

Mammalian cell culture

Communication skills

Team collaboration

Education

BA/BS + 8+ years

MS + 6+ years

Tools

Microsoft Office

GraphPad Prism

Benchling

MacVector

Job description

Build our future together:

At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Scientist to join our Viral Delivery Technologies group, supporting the development of a new screening platform for antibody-retargeted adeno-associated virus (AAV) vectors. In this role, you will contribute to the design, characterization, and in vitro/in vivo validation of novel AAV vectors, expanding the company’s gene therapy delivery portfolio while collaborating with cross-functional team members, analytical groups, and core facilities across Research and Discovery.

This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & where:

• Location: Tarrytown, NY
• Work model/flexibility: Onsite

Discover your role:

• Design, execute, analyze, and troubleshoot in vitro and in vivo experiments to characterize and validate antibody-retargeted viral vector designs and screening protocols
• Apply molecular biology and protein analysis techniques, including cloning, SDS-PAGE, Western blotting, DNA/RNA extraction, PCR, RT-PCR, digital droplet PCR, and qPCR
• Design AAV genomes and execute recombinant AAV (rAAV) production protocols to inform novel vector optimizations
• Develop, optimize, and troubleshoot next-generation sequencing (NGS) library preparation workflows for screening and characterization applications
• Partner with the bioinformatics team to analyze large NGS datasets
• Prepare regular updates and presentations for team and departmental forums
• Thrive in an innovative, highly collaborative, fast-paced environment
• Work rigorously with close attention to detail while balancing multiple projects

This role requires:

• B.A./B.S. with 8+ years of relevant industry or academic experience, or M.S. in cell biology, molecular biology, biochemistry, bioengineering, antibody science, or a related field with 6+ years of relevant experience
• Proficiency in next-generation sequencing (NGS), including library preparation, optimization, troubleshooting, and quality assessment
• Strong molecular biology experience, including DNA isolation, PCR-based methods, and plasmid cloning
• Experience in mammalian cell culture and manipulation, and in the purification of viruses and/or proteins
• Excellent presentation and communication skills
• Preferred: familiarity with key antibody properties, viral vector production, and relevant research software (e.g., Microsoft Office, GraphPad Prism, Benchling, MacVector)

Does this sound like you? We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship.

Please be advised that at Regeneron, we believe we do our best work when we are together. For that reason, many roles are required to be performed on‑site. Please speak with your recruiter and hiring manager for more information about on‑site expectations for your role and location.

As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications.

For jobs in Canada: this posting is for an existing position.

Please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/ For other locations, additional information will be provided during the recruitment process. If you have any questions, please speak with your recruiter.

Salary Range (annually)

$93,900.00 - $153,300.00