Scientist, NGS - Viral Delivery Technologies

Regeneron Pharmaceuticals, Inc (USA); Village of Tarrytown (NY); On-site; USD 94,000 - 153,000; Full time

Benefits offered by this job

Annual bonuses

Equity awards

Pension

401(k)

Health benefits

Paid time off

Family support

Job summary

Regeneron Pharmaceuticals, Inc (USA) seeks a Scientist to join its Viral Delivery Technologies group in Tarrytown, NY. You will design and validate AAV vectors and screening platforms, contributing to a fast-growing gene therapy portfolio.

The role requires strong molecular biology, NGS, and in vivo/in vitro experience, with collaboration across cross-functional teams. Onsite work model and a dynamic, innovations-driven environment.

Qualifications

• Strong molecular biology background with hands-on lab experience.
• Experience with DNA/RNA methods and cloning techniques.
• Experience in mammalian cell culture and viral/polypeptide purification.

Responsibilities

• Design, execute, analyze in vitro and in vivo experiments to characterize antibody-retargeted vector designs.
• Apply molecular biology methods including cloning, PCR, and sequencing techniques.
• Design AAV genomes and perform recombinant AAV production for vector optimization.
• Develop and optimize NGS library prep workflows for screening/characterization.
• Collaborate with bioinformatics to analyze large NGS datasets.
• Prepare updates and presentations for team and departmental forums.
• Work in a fast-paced, highly collaborative environment with attention to detail.

Skills

NGS proficiency

Molecular biology

Mammalian cell culture

Presentation skills

Communication skills

Education

BA/BS with 8+ years or MS with 6+ years in related field

Tools

SDS-PAGE

Western blotting

DNA/RNA extraction

PCR

RT-PCR

ddPCR

qPCR

Plasmid cloning

AAV production

Job description

Build our future together: At Regeneron, we use science and innovation to develop life-changing medicines for people with serious diseases. We are seeking a Scientist to join our Viral Delivery Technologies group, supporting the development of a new screening platform for antibody-retargeted adeno-associated virus (AAV) vectors. In this role, you will contribute to the design, characterization, and in vitro/in vivo validation of novel AAV vectors, expanding the company's gene therapy delivery portfolio while collaborating with cross-functional team members, analytical groups, and core facilities across Research and Discovery. This position offers the opportunity to contribute to a fast-growing, science-driven organization making a meaningful difference to patients worldwide.

When & where:

Location: Tarrytown, NY

Work model/flexibility: Onsite

Discover your role:

• Design, execute, analyze, and troubleshoot in vitro and in vivo experiments to characterize and validate antibody-retargeted viral vector designs and screening protocols
• Apply molecular biology and protein analysis techniques, including cloning, SDS-PAGE, Western blotting, DNA/RNA extraction, PCR, RT-PCR, digital droplet PCR, and qPCR
• Design AAV genomes and execute recombinant AAV (rAAV) production protocols to inform novel vector optimizations
• Develop, optimize, and troubleshoot next-generation sequencing (NGS) library preparation workflows for screening and characterization applications
• Partner with the bioinformatics team to analyze large NGS datasets
• Prepare regular updates and presentations for team and departmental forums
• Thrive in an innovative, highly collaborative, fast-paced environment
• Work rigorously with close attention to detail while balancing multiple projects

This role requires:

• B.A./B.S. with 8+ years of relevant industry or academic experience, or M.S. in cell biology, molecular biology, biochemistry, bioengineering, antibody science, or a related field with 6+ years of relevant experience
• Proficiency in next-generation sequencing (NGS), including library preparation, optimization, troubleshooting, and quality assessment
• Strong molecular biology experience, including DNA isolation, PCR-based methods, and plasmid cloning
• Experience in mammalian cell culture and manipulation, and in the purification of viruses and/or proteins
• Excellent presentation and communication skills

Preferred:

• familiarity with key antibody properties, viral vector production, and relevant research software (e.g., Microsoft Office, GraphPad Prism, Benchling, MacVector)

Does this sound like you?

We are committed to building a workplace with an inclusive culture. Regeneron is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion or belief (or lack thereof), sex, sexual orientation, gender identity or expression, gender reassignment, marital or civil partnership status, civil status, pregnancy or parental status, age, disability, nationality, citizenship status, ethnic or national origin, membership of the Traveler community, familial status, genetic information, military or veteran status, or any other characteristic protected under applicable law. Where required, we will provide reasonable accommodation to applicants with known disabilities or chronic illnesses during the recruitment process, unless such accommodation would impose undue hardship. Where necessary, we disclose salary ranges for roles in all countries in which we operate. The final offer will be determined within the relevant range based on the country of employment, specific role level, and your skills and experience. In some countries, collective bargaining agreements (CBAs) may apply and influence certain elements of pay or benefits. Regeneron offers a competitive and comprehensive total rewards package which may include, depending on country and role:

• annual bonuses or other incentive plans
• equity awards
• pension or retirement benefits
• 401(k) company match
• health and wellness programs
• fitness centers
• insurance benefits (e.g. medical, dental, vision, life and disability)
• paid time off
• family support benefits

For additional information about Regeneron benefits in the U.S., please visit https://careers.regeneron.com/en/working-at-regeneron/total-rewards/. For other locations, additional information will be provided during the recruitment process. Please be advised that at Regeneron, we believe we do our best work when we are together. As part of the recruitment process, certain background checks may be conducted in accordance with the laws of the country where the position is based. The purpose of such checks is to verify certain information prior to the commencement of employment such as identity, right to work and educational qualifications. For jobs in Canada: this posting is for an existing position. Salary Range (annually) $93,900.00 - $153,300.00

Regeneron is a leading biotechnology company that invents life-transforming medicines for people with serious diseases. Founded and led for over 30 years by physician-scientists, our unique ability to repeatedly and consistently translate science into medicine has led to nine FDA-approved treatments and numerous product candidates in development, almost all of which were homegrown in our laboratories. Our medicines and pipeline are designed to help patients with eye diseases, allergic and inflammatory diseases, cancer, cardiovascular and metabolic diseases, neurology, infectious diseases and rare diseases. Regeneron is also proud of award winning culture of innovation, being recognized as a Great Place to Work in 2021, Fast Company’s Best Workplace for Innovators in 2020, and Forbes JUST companies in 2020, among others.