Scientist - Lipid Nanoparticle (LNP) Formulation

Rose International; San Diego (CA); On-site; USD 95,000 - 140,000; Full time

Job summary

Rose International seeks a motivated Scientist 1 to join our Formulation team. You will directly work with senior scientists to synthesize and optimize lipid nanoparticles (LNPs) for nucleic acid delivery, collaborating across teams to meet project goals.

The role emphasizes hands-on formulation, data analysis, and detailed documentation in a fast-paced environment. Prior LNP experience and strong analytical skills are highly valued.

Qualifications

• Bachelor’s degree with 5+ years biopharma experience or Master’s with 2+ years industry experience.
• LNP formulation and encapsulation experience required (2+ years).
• Proficiency with LNP characterization methods (DLS, zeta potential, Ribogreen).
• Strong data analysis and documentation skills; attention to detail.

Responsibilities

• Formulate and characterize lipid nanoparticles (LNPs) for in vitro/in vivo studies.
• Implement DoE-based screening to optimize LNP compositions and processing.
• Collaborate with cross-functional teams to fulfill formulation requests.
• Support early-stage formulation development, including scale-up and stability studies.
• Maintain detailed records and present data to the formulation team.

Skills

LNP expertise

Analytical skills

MS Excel

JMP

Prism

DoE / data analysis

Communication

Attention to detail

Team collaboration

Education

Bachelor’s degree in Chemistry/Biochemistry/Chemical Engineering or related (5+ years biopharma)

Master’s degree with 2+ years industry experience

Tools

Excel

JMP

Prism

Job description

• Bachelor’s degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience.
• OR a Master’s degree with 2+ years of industry experience.
  

Education

• Bachelor’s degree in Chemistry, Biochemistry, Chemical Engineering, or a related discipline with 5+ years of biopharma industry experience.
• OR a Master’s degree with 2+ years of industry experience.
  

Required Skills

• LNP Expertise: Minimum of 2 years of hands-on laboratory experience specializing in LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Analytical Skills: Proficiency with standard LNP characterization methods, including Dynamic Light Scattering (DLS), Zeta potential, and Ribogreen assays.
• Software & Data: High proficiency in MS Excel is required; hands-on experience with statistical and data analysis software (e.g., JMP, Prism) is preferred.
• Core Competencies: Strong attention to detail, a track record of producing reproducible data, excellent organizational skills, and the ability to communicate effectively within a fast-paced team environment.
  

Preferred Skills

• Prior experience with targeted LNP preparation (mAb, Fab, ScFv, VHH coated LNP) and immune cell delivery is highly desirable.
  

Summary

• We are seeking a motivated and detail-oriented Scientist 1 to join our Formulation team.
• In this hands-on laboratory role, you will work closely with senior scientists to execute and optimize the synthesis of targeted and non-targeted lipid nanoparticles (LNPs) for nucleic acid delivery.
• The successful candidate will be a collaborative team player with strong technical and data analysis skills who is ready to contribute to our non-viral delivery platform.
  

Responsibilities

• Execute and optimize the formulation and characterization of lipid nanoparticles (LNPs) or targeted lipid nanoparticle (tLNPs) encapsulating nucleic acids for in vitro and in vivo studies under the minor guidance of senior formulation scientists.
• Implement Design of Experiment (DoE) based screening campaigns to evaluate and establish optimal LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to support and fulfill formulation requests.
• Support early-stage formulation development and downstream processing activities when needed, including cryoprotection, scale-up, and stability studies.
• Maintain detailed records documenting formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management activities, including inventory tracking, supply ordering, buffer preparation, and autoclaving.
• **Only those lawfully authorized to work in the designated country associated with the position will be considered.**
• **Please note that all Position start dates and duration are estimates and may be reduced or lengthened based upon a client’s business needs and requirements.**
  

About Rose

• Founded in 1993
• Office Locations Across the U.S.
• 150+ Clients: Corporations and Government Agencies
• Employee Oriented Company
• Challenging Assignments Across the U.S.
• Continuous Professional Development
  

EMPLOYEE COMMENTS

• We want you to work with us, but don't take our word for it. Take a look at this sampling of employee comments. They speak for themselves.