Scientist, In Vivo Pharmacology

Flagship Pioneering; Cambridge (MA); On-site; USD 100,000 - 143,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Job summary

Serif Biomedicines seeks an experienced scientist to join the in vivo pharmacology group, reporting to the head of pharmacology. You will execute preclinical studies in rodent models, including humanized mice, to support exploratory and therapeutic programs, in collaboration with CROs.

This hands-on role requires close collaboration with multidisciplinary teams in a fast-paced, highly collaborative environment and involves animal procedures, protocol development, and data analysis to advance

Qualifications

• MS with 10+ years or BS with 12+ years industry experience.
• Hands-on experience in mouse models of immunology, oncology and transgenic reporter models.
• Experience with IVIS acquisition and analysis.
• Experience writing IACUC protocols.
• Strong organizational and communication skills.
• Ability to thrive in a fast-paced, growing biotech environment.

Responsibilities

• Execute and oversee in vivo efficacy, biodistribution, PK/PD in rodent models including humanized mice, xenograft, syngeneic, and transgenic models.
• Contribute to study designs, study planning, and resource allocation with the head of Pharmacology.
• Perform animal procedures including blood collection, necropsy, tissue harvest, and dosing through multiple routes (IM, SC, IV, IP).
• Author protocols for rodent studies and contribute to NHP protocols; oversee studies at vivariums/CROs.
• Establish and maintain relationships with vivarium and external CROs for high-quality, timely execution.
• Perform dose calculations and prepare dosing formulations for rodent and NHP studies; coordinate shipments.
• Ensure study compliance with IACUC and company policies; maintain records.
• Demonstrate scientific and technical expertise to advance in vivo studies and communicate results.
• Proactively develop creative solutions for technical and scientific issues.
• Analyze relevant tolerability endpoints and communicate results to stakeholders.

Skills

Mouse models

IVIS imaging

IACUC protocols

Data analysis

Team collaboration

Education

MS with 10+ years

BS with 12+ years

Tools

IVIS imaging

Job description

Company Summary:

Serif Biomedicines is a privately held, early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif Biomedicines was founded by Flagship Pioneering, an innovation enterprise that conceives, creates, resources, and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years, all of which are pioneering novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA), Syros Pharmaceuticals (SYRS), Seres Therapeutics (NASDAQ:MCRB), Generate Biomedicines, Tessera Tx, Evelo Biosciences (EVLO), and Indigo Agriculture.

Position Summary:

We are looking for an experienced scientist to join the in vivo pharmacology group at Serif. This position will report to the head of pharmacology and will focus on executing preclinical studies in rodent models, including humanized mouse models, to support exploratory and therapeutic programs, both internally and in collaboration with CROs. This is a hands‑on role that involves close collaboration with multi‑disciplinary teams in a fast‑paced, highly collaborative environment.

Key Responsibilities:

• Execute and oversee in vivo efficacy, biodistribution, PK/PD in rodent models including humanized mice, xenograft, syngeneic, and transgenic mouse models relevant to platform and therapeutic programs.
• Contribute to study designs, study planning, and resource allocation of in vivo studies by working in close collaboration with head of Pharmacology
• Perform animal procedures including blood collection, necropsy, tissue harvest, and homogenization, cell isolation, and test article administration through multiple routes, including I.M, S.C, I.V, I.P.

Author protocols for rodent studies and contribute to NHP protocols as needed and oversee/conduct in vivo rodent studies at contract vivariums and/or CROs.

• Establish and maintain strong relationships with vivarium and external CRO to ensure high quality and timely execution of studies.
• Perform dose calculations and prepare dosing formulations for rodent and NHP studies. Coordinate shipment of test articles to CROs and the receipt of samples, ensuring timely communication with stakeholders.
• Ensure study compliance with IACUC protocols, and company policies.
• Maintain accurate experimental records, study protocols and reports.
• Demonstrate scientific and technical expertise to advance in vivo studies through familiarity with scientific literature.
• Proactively recognize and develop creative solutions for emerging technical and scientific issues.
• Analyze relevant tolerability endpoints and effectively communicate results to stakeholders.

Required Qualifications:

• M.S with 10+ or B.S with 12+ years industry experience, respectively. Level will be based on experience and demonstrated scope.
• Proficient hands‑on experience in mouse models of immunology, oncology and transgenic reporter models. Experience with IVIS acquisition and analysis preferred.
• Experience in writing IACUC protocols required. Familiarity with NHP protocols preferred.
• Experience performing in‑vivo procedures in rodents, including dose preparation and administration of therapeutics and sample collection (blood, tissues etc.) and processing required
• Strong organizational, communication and interpersonal skills.
• Ability to thrive in a fast‑paced, and rapidly growing biotech environment with changing priorities.
• Work independently and collaboratively in a multidisciplinary team environment.

At Flagship, we recognize there is no perfect candidate. If you have some of the experience listed above but not all, please apply anyway. Experience comes in many forms, skills are transferable, and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Serif Biomedicines currently offers healthcare coverage, annual incentive program, retirement benefits and a broad range of other benefits.

• healthcare coverage
• annual incentive program
• retirement benefits
• a broad range of other benefits

The salary range for this role is $100,000 - $143,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience.