In Vivo Pharmacology Scientist – Preclinical Rodent Models

Flagship Pioneering, Inc.; Cambridge (MA); On-site; USD 100,000 - 143,000; Full time

Benefits offered by this job

Healthcare coverage

Annual incentive program

Retirement benefits

Broad range of other benefits

Job summary

Serif Biomedicines seeks an experienced scientist to join the in vivo pharmacology group, reporting to the head of pharmacology. You will execute preclinical studies in rodent models, including humanized mice, to support exploratory and therapeutic programs, in collaboration with CROs.

This hands-on role requires close collaboration with multidisciplinary teams in a fast-paced, highly collaborative environment and involves animal procedures, protocol development, and data analysis to advance

Qualifications

• MS with 10+ years or BS with 12+ years industry experience.
• Hands-on experience in mouse models of immunology, oncology and transgenic reporter models.
• Experience with IVIS acquisition and analysis.
• Experience writing IACUC protocols.
• Strong organizational and communication skills.
• Ability to thrive in a fast-paced, growing biotech environment.

Responsibilities

• Execute and oversee in vivo efficacy, biodistribution, PK/PD in rodent models including humanized mice, xenograft, syngeneic, and transgenic models.
• Contribute to study designs, study planning, and resource allocation with the head of Pharmacology.
• Perform animal procedures including blood collection, necropsy, tissue harvest, and dosing through multiple routes (IM, SC, IV, IP).
• Author protocols for rodent studies and contribute to NHP protocols; oversee studies at vivariums/CROs.
• Establish and maintain relationships with vivarium and external CROs for high-quality, timely execution.
• Perform dose calculations and prepare dosing formulations for rodent and NHP studies; coordinate shipments.
• Ensure study compliance with IACUC and company policies; maintain records.
• Demonstrate scientific and technical expertise to advance in vivo studies and communicate results.
• Proactively develop creative solutions for technical and scientific issues.
• Analyze relevant tolerability endpoints and communicate results to stakeholders.

Skills

Mouse models

IVIS imaging

IACUC protocols

Data analysis

Team collaboration

Education

MS with 10+ years

BS with 12+ years

Tools

IVIS imaging

Job description

Serif Biomedicines seeks an experienced scientist to join the in vivo pharmacology group, reporting to the head of pharmacology. You will execute preclinical studies in rodent models, including humanized mice, to support exploratory and therapeutic programs, in collaboration with CROs.

This hands-on role requires close collaboration with multidisciplinary teams in a fast-paced, highly collaborative environment and involves animal procedures, protocol development, and data analysis to advance