Scientist, In Vivo Cancer Modeling

Cloverleaf Bio; Boston (MA); On-site; USD 120,000 - 180,000; Full time

Benefits offered by this job

Equity incentives

Medical/Dental/Vision

401k with employer match

Fast-paced environment

Job summary

Cloverleaf Bio is seeking an experienced in vivo Scientist in Boston to help create a novel family of RNA therapeutics. You will design and execute mouse studies, collaborate with the founding team, and guide pharmacology and toxicity work to advance development.

The role requires hands-on mouse work, data analysis, and ability to coordinate CRO studies in a fast-paced startup environment.

Qualifications

• PhD required in cancer biology, molecular biology, or related field.
• Hands-on experience with mouse models of disease (oncology preferred).
• Ability to independently plan and execute in vivo studies and analyze data.

Responsibilities

• Design and execute in-house animal experiments in mice.
• Coordinate toxicity, pharmacology, and efficacy studies at CROs.
• Perform in vitro experiments to characterize mechanism and potency.
• Provide in vivo pharmacology/expertise to accelerate tRNA therapeutics development.

Skills

Mouse models

Tissue collection & processing

Intravenous & subcutaneous injections

In vivo study planning

Data analysis & interpretation

Mammalian cell culture

Molecular biology techniques

Education

PhD in Cancer Biology, Molecular Biology, or related fields

Job description

About Us

Cloverleaf Bio is an early-stage therapeutics company that is developing a new class of engineered RNA therapeutics.

The Job

We are seeking an experienced in vivo Scientist to join our team. In this position, you will work in close conjunction with our founding team in the creation and development of a completely novel family of RNA therapeutics.

Your responsibilities will include designing and executing in house animal experiments in mice, proposing, planning and coordinating toxicity, pharmacology and efficacy studies at CROs, performing in vitro experiments to characterize the mechanism and potency of candidate RNAs, and providing in vivo pharmacology and physiology expertise to accelerate development of our tRNA therapeutics.

When & Where

Location: Boston, MA

Work Model: Full-time onsite

About You

Excited by the science. We are excited by how science can improve the world and are looking for people who are too.

Flexible. We wear many different hats and are looking for people who are willing to do whatever it takes to pitch in and get the job done.

Resilient. Working in an early-stage startup can be hard. Science is hard. We are looking for people who have a demonstrated track record of sticking with complex problems for the long haul.

Cooperative. As a small team, communication and collaboration are key. We are looking for people who thrive working both independently and collaboratively.

Qualifications

• PhD in Cancer Biology, Molecular Biology, or related fields.


• Must have hands-on experience with mouse models of disease (preferably oncology), tissue collection and processing, and routine drug administration including intravenous and subcutaneous injections.


• Demonstrated ability to independently plan and execute in-vivo studies, data analysis and interpretation.


• Skilled in mammalian cell culture and molecular biology techniques.

Nice to haves

• Strong molecular/cell biology experience, particularly in immunology, RNA biochemistry and/or protein biochemistry.


• Hands-on experience with flow cytometry, IHC, ELISA.


• Experience with design/development RNA therapeutics and lipid nanoparticles.


• Previous experience selecting and overseeing work at CROs.

Benefits

• Competitive salary commensurate with experience and strong equity incentives.


• Medical, dental, and vision coverage.


• 401k retirement including employer match.


• A stimulating, collegial, and fast-paced environment.